RESEARCH PAPER
Vitamin D3 levels in healthy people, including a group aged over 60, in relation to BMI
 
More details
Hide details
1
Faculty of Medicine, University of Rzeszow, Poland
 
2
Subcarpathian Centre of Lung Diseases – Clinic of Pulmonology and Allergology, Rzeszow, Poland
 
3
Department of Hygiene of Nutrition and Epidemiology, Medical University, Lodz, Poland
 
 
Corresponding author
Sławomir Tokarski
Sławomir Tokarski MD PhD, ul. Rycerska 2, 35-241 Rzeszów, Poland
 
 
J Pre Clin Clin Res. 2017;11(1):25-29
 
KEYWORDS
ABSTRACT
Vitamin D plays a role not only in the remodeling of bone, but also in functions involving other organs. Its tissue availability depends on dermal synthesis and/or ingestion from diet, as well as on the amount of adipose tissue binding vitamin D into its cells. This study evaluates vitamin D concentrations in relation to body-mass index (BMI) in healthy people aged over 60 and living in the Subcarpathian Province of southeastern Poland. The study involved 246 participants – 172 women (69.9%), 74 men (31,1%), with an average age of 65.9 (±11.9). The mean concentrations of vitamin D, assessed with ECLIA method, was 18 ng/ml, which indicates a marked deficiency in vitamin D. Defined vitamin D deficiency (<20ng/ml) was noted in 62% of participants without any difference between males and females. There was no correlation between BMI and vitamin D deficiency in the studied group. The results suggest the need for vitamin supplementation in healthy people aged over 60 according to the guidelines
 
REFERENCES (33)
1.
Holick M. Vitamin D deficiency. N Engl J Med. 2007; 357: 266–281.
 
2.
Armas LA, Dowell S, Akhter M, et al. Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: the effect of UVB dose and skin color. J Am Acad Dermatol. 2007; 57: 588–593.
 
3.
Alpert PT, Shaikh U. The effects of vitamin D deficiency and insufficiency on the endocrine and paracrine systems. Biol Res Nurs. 2007; 9: 117–129.
 
4.
Grygiel-Górniak B, Puszczewicz M. Witamina D – nowe spojrzenie w medycynie i reumatologii. Postępy Hig Med Dosw (online) 2014; 68: 359–368.
 
5.
Pawliczak R. Witamina D – znaczenie w chorobach obturacyjnych. Zjawisko stare, dane kliniczne nowe. Terapia 2014; 9(2): 21–25.
 
6.
Bonakdar ZS, Jahanshahifar L, Jahanshahifar F, Gholamrezaei A. Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus. Lupus, 2011; 20: 1155–1160.
 
7.
Haussler MR, Norman A. Chromosomal receptor for a vitamin D metabolite. Proc Natl Acad Sci. USA, 1969; 62: 155–162.
 
8.
DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004; 80: 1689–1696.
 
9.
DeLuca HF, Cantorna M. Vitamin D: its role and uses in immunology. FASEB J, 2001; 15: 2579–2585.
 
10.
Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J ClinNutr. 2008; 87(4): 1080–1086.
 
11.
Abbas MA. Physiological functions of vitamin D in adipose tissue. J Steroid Biochem Mol Biol. 2017; 165: 369–381.
 
12.
Koszowska AU, Nowak J, Dittfeld A, et al. Obesity, adipose tissue function and the role of vitamin D. Centr Eur J Immunol. 2014; 39: 260–264.
 
13.
Mehmood ZTNH. Papandreou D: An updated mini review of vitamin D and obesity: adipogenesis and inflammation state. Open Access Maced. J Med. 2016; 4: 526–532.
 
14.
Bruyere O, Slomian J, Beaudart C, et al. Prevalence of vitamin D inadequacy in European women aged over 80 years. Arch Gerontol Geriatr. 2014; 59: 78–82.
 
15.
Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001; 22: 477–501.
 
16.
Charzewska J, Chlebna-Sokół D, Chybicka A. i wsp. Aktualne (2009) polskie zalecenia dotyczące profilaktyki niedoboru witaminy D. Med. Prakt Pediatr. 2010; 1: 40–46.
 
17.
Karczmarewicz E, Czekuć-Kryśkiewicz E, Płudowski P. Effect of vitamin D status on pharmacological treatment efficiency. Dermatoloendocrinol. 2013; 5: 1–6.
 
18.
Marcinkowska-Suchowierska E, Walicka M. Niedobory witaminy D -narastający problem społeczny. Fam Med Prim Care Rev. 2009; 11: 691–69.
 
19.
Kramer J, Diehl A, Lehnert H. Epidmiological study on the dimension of vitamin D deficiency in North Germany. Dtsch Med Wochenschr. 2014; 139(10): 470–475.
 
20.
Valtueňa J, Gonzales-Gross M, Hybrechts I, et al. Factors associatedwith vitamin D defficiency in European adolescens: the Helena Study. J Nutr Sci Vitaminol. 2013; 59(3): 161–171.
 
21.
Kaehler ST, Baumgartner H, Jeske M, et al. Prevalence of hypovitaminosis D and folate deficiency in healthy young female Austrian students in a health care profession. Eur J Nut. 2012; 51(8): 1021–1031.
 
22.
Marcinkowska-Suchowierska E, Walicka M. Niedobory witaminy D – narastający problem społeczny. Fam Med Prim Care Rev. 2009; 11: 691–698.
 
23.
Bruyere O, Malaise O, Neuprez A, et al. Prevalence of vitamin D inadequacy in European postmenopausal women. Curr Med Res Opin. 2007; 23(8): 1939–1944.
 
24.
Gaugris S, Heaney RP, Boonen S, et al. Vitamin D inadequacy among postmenopausal women: a systematic review. QJM. 2005; 98(9): 667–676.
 
25.
Merlo C, Ross C, Trummler M, et al. Prevalence and symptoms of vitamin D deficiency in general practice. Praxis. 2012; 101(22): 1417– 1422.
 
26.
Napiórkowska L, Budlewski T, Jakubas-Kwiatkowska i wsp. Częstość występowania małego stężenia witaminy D w surowicy starszych kobiet w Polsce. Pol Arch Med Wewn. 2009; 119: 669.
 
27.
Kaczmarewicz E, Łukaszkiewicz J, Lorenc R. Witamina D — mechanizm działania, badania epidemiologiczne, zasady suplementacji. Lab Forum 2007; 11: 3–8.
 
28.
Lucas J, Bolland M, Grey A, et al. Determinants of vitamin D status in older women living in a subtropical climate. Osteoporo Int. 2005; 16: 1641–1648.
 
29.
Saadi H, Nagelkerke N, Benedict S, et al. Predictors and relationships of serum 25-hydroxyvitamin D concentration with bone turnover markers, bone mineral density, and vitamin D receptor genotype in Emirati women. Bone 2006; 39: 1136–1143.
 
30.
Hannemann A, Thuesen BH, Friedrich N et al. Adiposity measures and vitamin D concentrations in Northeast Germany and Denmark. Nutr Metab (Lond). 2015; 10,12: 24.
 
31.
Czerwińska E, et al. Calcium homeostasis and biochemical markers of bone turnover in patients with morbid obesity. Obesity Reviews 2006; 7(Suppl 2): 139.
 
32.
Dhaliwal R, Mikhail M, Feuerman M et al. The vitamin d dose response in obesity. EndocrPract. 2014; 20: 12.
 
33.
Wortsman J, et al. Decreased bioavailability of vitamin D in obesity.Am J Clin Nutr. 2000; 72: 690–693.
 
eISSN:1898-7516
ISSN:1898-2395
Journals System - logo
Scroll to top