REVIEW PAPER
Urinary proteomic strategies in biomarkers discovery of renal diseases
1
Faculty of Biotechnology and Animal Husbandry; Department of Physiology, Cytobiology and Proteomics, West Pomeranian University of Technology, Szczecin, Poland
Corresponding author
J Pre Clin Clin Res. 2011;5(1):1-6
KEYWORDS
ABSTRACT
Proteomic analysis have been commonly used in numerous studies in the field of renal medicine. However, invasive tissue sampling and also its small quantity are the main obstacles in this type of analysis. Urine might be a suitable alternative for kidney puncture as it can be collected in a non-invasive way, in large amounts, and it also contains proteins, peptides and amino acids. Therefore, attempts have been made to identify urinary biomarkers for renal diseases, such as: IgA nephropathy, membranous nephropathy, idiopathic nephritic syndrome, steroid-resistant nephritic syndrome, steroid- sensitive nephritic syndrome, diabetic nephropathy, uretopelvic junction obstruction, radiation nephropathy and chronic kidney disease. The search for novel protein markers, which may enable early detection of the above-mentioned kidney diseases, requires the application of several, different proteomic techniques. This review is intended to discuss the present state of knowledge within this subject.
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