CASE REPORT
The use of stem cells in the treatment of cerebral palsy
More details
Hide details
1
Department of Child Neurology, Medical University, Lublin, Poland
J Pre Clin Clin Res. 2023;17(3):208-211
KEYWORDS
TOPICS
ABSTRACT
Cerebral Palsy (CP) is one of the most common reasons for physical disability in children. There are numerous factors that affect the development of this disease which occur predominantly in the perinatal period. The aim of this report is to highlight new possibilities for treating cerebral palsy with stem cells, based on a literature review with the focus on a clinical case from a Child Neurology Department in Lublin, eastern Poland. To date, treatment methods have not had good results. A future alternative is the administration of stem cells. The clinical case presented is evidence that further research is needed to improve this new treatment method. Among all the symptoms of CP, the most important is reduction in muscle tone in the children, and stem cell administration reduces the spasticity. Intensive rehabilitation and support from psychologists and neurologists are still the primary means of improving the performance of patients with CP.
Ziółkiewicz A, Jartych A, Więsyk P, Bielak M, Biel N, Chrościńska-Krawczyk M. The use of stem cells in the treatment of Cerebral Palsy. J Pre-Clin Cin Res. 2023; 17(3): 208–211. doi: 10.26444/jpccr/171305
REFERENCES (21)
1.
Vitrikas K, Dalton H, Breish D. Cerebral Palsy: An Overview. Am Fam Physician. 2020 Feb 15;101(4):213–220. PMID: 32053326.
2.
Mann JR, McDermott S, Bao H, et al. Maternal genitourinary infection and risk of cerebral palsy. Dev Med Child Neurol. 2009 Apr;51(4):282–8.
https://doi.org/10.1111/j.1469....
3.
Ayubi E, Sarhadi S, Mansori K. Maternal Infection During Pregnancy and Risk of Cerebral Palsy in Children: A Systematic Review and Meta-analysis. J Child Neurol. 2021 Apr;36(5):385–402.
https://doi.org/10.1177/088307....
5.
Kurjak A, Predojevic M, Stanojevic M, et al. Intrauterine growth restriction and cerebral palsy. Acta Inform Med. 2012 Jan;18(2):64–82.
https://doi.org/ 10.5455/aim.2010.18.64-82.
6.
Petersen TG, Liew Z, Andersen AN, et al. Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child. Int J Epidemiol. 2018 Feb 1;47(1):121–130.
https://doi.org/10.1093/ije/dy....
8.
Novak I, Morgan C, Adde L, et al. Early, Accurate Diagnosis and Early Intervention in Cerebral Palsy: Advances in Diagnosis and Treatment. JAMA Pediatr. 2017 Sep 1;171(9):897–907. Erratum in: JAMA Pediatr. 2017 Sep 1;171(9):919.
https://doi.org/10.1001/jamape....
9.
Muñoz-Blanco E, Merino-Andrés J, Aguilar-Soto B, et al. Influence of Aquatic Therapy in Children and Youth with Cerebral Palsy: A Qualitative Case Study in a Special Education School. Int J Environ Res Public Health. 2020 May 23;17(10):3690.
https://doi.org/10.3390/ijerph....
10.
Booth ATC, Buizer AI, Meyns P, et al. The efficacy of functional gait training in children and young adults with cerebral palsy: a systematic review and meta-analysis. Dev Med Child Neurol. 2018 Sep;60(9):866–883.
https://doi.org/10.1111/dmcn.1....
12.
Matusiak-Wieczorek E, Dziankowska-Zaborszczyk E, Synder M, et al. The Influence of Hippotherapy on the Body Posture in a Sitting Position among Children with Cerebral Palsy. Int J Environ Res Public Health. 2020 Sep 19;17(18):6846.
https://doi.org/10.3390/ijerph....
13.
Shintaku H. Prevention and treatment of cerebral palsy with cord blood stem cells and cord-derived mesenchymal stem cells. Neural Regen Res. 2021 Apr;16(4):672–673.
https://doi.org/10.4103/1673-5....
14.
Wang Y, Pan J, Wang D, et al. The Use of Stem Cells in Neural Regeneration: A Review of Current Opinion. Curr Stem Cell Res Ther. 2018;13(7):608–617.
https://doi.org/10.2174/157488....
15.
Zakrzewski W, Dobrzyński M, Szymonowicz M, et al. Stem cells: past, present, and future. Stem Cell Res Ther. 2019 Feb 26;10(1):68.
https://doi.org/10.1186/s13287....
16.
Vankeshwaram V, Maheshwary A, Mohite D, et al. Is Stem Cell Therapy the New Savior for Cerebral Palsy Patients? A Review. Cureus. 2020 Sep 2;12(9):e10214.
https://doi.org/10.7759/cureus....
17.
Sun JM, Kurtzberg J. Stem cell therapies in cerebral palsy and autism spectrum disorder. Dev Med Child Neurol. 2021 May;63(5):503–510.
https://doi.org/10.1111/dmcn.1....
18.
Lv ZY, Li Y, Liu J. Progress in clinical trials of stem cell therapy for cerebral palsy. Neural Regen Res. 2021 Jul;16(7):1377–1382.
https://doi.org/10.4103/1673-5....
19.
Sun JM, Song AW, Case LE, et al. Effect of Autologous Cord Blood Infusion on Motor Function and Brain Connectivity in Young Children with Cerebral Palsy: A Randomized, Placebo-Controlled Trial. Stem Cells Transl Med. 2017 Dec;6(12):2071–2078.
https://doi.org/10.1002/sctm.1....
20.
Feng M, Lu A, Gao H, et al. Safety of Allogeneic Umbilical Cord Blood Stem Cells Therapy in Patients with Severe Cerebral Palsy: A Retrospective Study. Stem Cells Int. 2015;2015:325652.
https://doi.org/10.1155/2015/3....
21.
Bae SH, Lee HS, Kang MS, et al. The levels of pro-inflammatory factors are significantly decreased in cerebral palsy patients following an allogeneic umbilical cord blood cell transplant. Int J Stem Cells. 2012 May;5(1):31–8.
https://doi.org/10.15283/ijsc.....