REVIEW PAPER
The role of flavonoids in the treatment of periodontal diseases – literature review
1
Academic Centre for Dentistry and Specialised Medicine in Bytom, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland
2
Dr. B. Hager Multispecialty County Hospital, Tarnowskie Góry, Poland
3
Regional Specialist Hospital No. 4, Bytom, Poland
4
Academic Centre for Dentistry and Specialised Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland
Corresponding author
Jakub Adamczyk
Academic Centre for Dentistry and Specialised Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Plac Akademicki 17, 41-902 Bytom, Poland
Academic Centre for Dentistry and Specialised Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Plac Akademicki 17, 41-902 Bytom, Poland
J Pre Clin Clin Res. 2022;16(4):153-156
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
Periodontal disease is one of the many diseases of the oral cavit. Periodontium is defined as the tissues that surround and hold the tooth in the socket. Periodontitis may lead to the loss of hard and soft tissues, resulting in the loss of dentition. The current standards for the treatment of periodontal disease are based on both surgical treatment and non-surgical treatment. The subject of research among many scientists is the effect of flavonoids – substances of plant origin, on periodontal diseases. This literature review aims to present the possibility of using flavonoids as adjunctive treatment in periodontal diseases.
Review methods:
Articles in English were searched using PubMed databases to evaluate the effect of flavonoids in the prevention and treatment of periodontal disease. The bibliography was reviewed to eliminate duplicate works.
Brief description of the state of knowledge:
The anti-inflammatory, antibacterial and antiresorptive properties of flavonoids are the main factors influencing their use in the prevention of periodontal disease. Thanks to these three properties, the risk of periodontal disease is significantly reduced, which is why extracts from plants with a high flavonoid content are increasingly used in products for daily oral hygiene.
Summary:
The antibacterial, anti-inflammatory and antiresorptive effects of flavonoids make them an important factor in the treatment of periodontal disease. Further research in the use of natural medicinal substances of plant origin is an important aspect for the development of modern medicine.
Periodontal disease is one of the many diseases of the oral cavit. Periodontium is defined as the tissues that surround and hold the tooth in the socket. Periodontitis may lead to the loss of hard and soft tissues, resulting in the loss of dentition. The current standards for the treatment of periodontal disease are based on both surgical treatment and non-surgical treatment. The subject of research among many scientists is the effect of flavonoids – substances of plant origin, on periodontal diseases. This literature review aims to present the possibility of using flavonoids as adjunctive treatment in periodontal diseases.
Review methods:
Articles in English were searched using PubMed databases to evaluate the effect of flavonoids in the prevention and treatment of periodontal disease. The bibliography was reviewed to eliminate duplicate works.
Brief description of the state of knowledge:
The anti-inflammatory, antibacterial and antiresorptive properties of flavonoids are the main factors influencing their use in the prevention of periodontal disease. Thanks to these three properties, the risk of periodontal disease is significantly reduced, which is why extracts from plants with a high flavonoid content are increasingly used in products for daily oral hygiene.
Summary:
The antibacterial, anti-inflammatory and antiresorptive effects of flavonoids make them an important factor in the treatment of periodontal disease. Further research in the use of natural medicinal substances of plant origin is an important aspect for the development of modern medicine.
Adamczyk J, Chwałowska M, Gębka N, Stós K, Jakubowicz N, Gabryś-Kwolek A, Rój R. The role of flavonoids in the treatment of periodontal
diseases – a literature review. J Pre-Clin Clin Res. 2022; 16(4): 153–156. doi: 10.26444/jpccr/156979
REFERENCES (17)
1.
Ostrowska J, Skrzydlewska E. Aktywność biologiczna flawonoidów. Borgis – Postępy Fitoterapii. 2005; 3–4:71–79.
2.
Varela-López A, Bullón P, Giampieri F, et al. Non-Nutrient, Naturally Occurring Phenolic Compounds with Antioxidant Activity for the Prevention and Treatment of Periodontal Diseases. Antioxidants (Basel). 2015;4(3):447–81. https://doi.org/10.3390/antiox....
3.
Jayusman PA, Nasruddin NS, Mahamad Apandi NI, et al. Therapeutic Potential of Polyphenol and Nanoparticles Mediated Delivery in Periodontal Inflammation: A Review of Current Trends and Future Perspectives. Front Pharmacol. 2022;13:847702. https://doi.org/10.3389/fphar.....
5.
Fernández-Rojas B, Gutiérrez-Venegas G. Flavonoids exert multiple periodontic benefits including anti-inflammatory, periodontal ligament-supporting, and alveolar bone-preserving effects. Life Sci. 2018;209:435–454. https://doi.org/10.1016/j.lfs.....
6.
Majewska M, Czeczot H. Flawonoidy w profilaktyce i terapii. Farm Pol. 2009;65(5):369–377.
7.
Jasiński M, Mazurkiewicz E, Rodziewicz P, et al. Flawonoidy – budowa, właściwości i funkcja ze szczególnym uwzględnieniem roślin motylkowatych. Biotechnologia. 2009;2(85):81–94.
8.
Carvalho JS, Ramadan D, de Paiva Gonçalves V, et al. Impact of citrus flavonoid supplementation on inflammation in lipopolysaccharide-induced periodontal disease in mice. Food Funct. 2021;12(11):5007–5017. https://doi.org/10.1039/d0fo03....
9.
Mooney EC, Holden SE, Xia XJ, et al. Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis. Front Immunol. 2021;12:774273. https://doi.org/10.3389/fimmu.....
10.
Xiong G, Ji W, Wang F, et al. Quercetin Inhibits Inflammatory Response Induced by LPS from Porphyromonas gingivalis in Human Gingival Fibroblasts via Suppressing NF-κB Signaling Pathway. Biomed Res Int. 2019;20:6282635. https://doi.org/10.1155/2019/6....
11.
Gutiérrez-Venegas G, Contreras-Sánchez A, Ventura-Arroyo JA. Anti-inflammatory activity of fisetin in human gingival fibroblasts treated with lipopolysaccharide. J Asian Nat Prod Res. 2014;16(10):1009–17. https://doi.org/10.1080/102860....
12.
Gomez-Florit M, Pacha-Olivenza MA, Fernández-Calderón MC, et al. Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria. Sci Rep. 2016;6:22444. https://doi.org/10.1038/srep22....
13.
Li J, Peng Y. Effect of puerarin on osteogenic differentiation of human periodontal ligament stem cells. J Int Med Res. 2020;48:300060519851641. https://doi.org/10.1177/030006....
14.
Ming J, Zhuoneng L, Guangxun Z. Protective role of flavonoid baicalin from Scutellaria baicalensis in periodontal disease pathogenesis: A literature review. Complement Ther Med.2018;38:11–18. https://doi.org/10.1016/j.ctim....
15.
Matsumoto S, Tominari T, Matsumoto C, et al. Effects of Polymethoxyflavonoids on Bone Loss Induced by Estrogen Deficiency and by LPS-Dependent Inflammation in Mice. Pharmaceuticals (Basel). 2018;11(1):7. https://doi.org/10.3390/ph1101....
16.
Gómez-Florit M, Monjo M, Ramis JM. Quercitrin for periodontal regeneration: effects on human gingival fibroblasts and mesenchymal stem cells. Sci Rep. 2015;12:16593. https://doi.org/10.1038/srep16....
17.
Zhang W, Jia L, Zhao B, et al. Quercetin reverses TNF‑α induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF‑κB/NLRP3 inflammasome pathway. Int J Mol Med. 2021;47:39. https://doi.org/10.3892/ijmm.2....
Share
RELATED ARTICLE
| eISSN: | 1898-7516 |
| ISSN: | 1898-2395 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
