The quality of life for patients with schizophrenia is an important issue nowadays, as the idea of de-institutionalisation in psychiatry is being implemented. The aim of this study was to analyze different determinants of the quality of life in patients with schizophrenia. The survey covered a group of 115 patients with schizophrenia from community mental health service centres in the Lublin Province of eastern Poland. The following methods were used: WHOQOL-BREF (WHO Quality of Life, BREF is a shorter version of the original instrument that may be more convenient for use in large research studies or clinical trials), HADS (Hamilton Anxiety and Depression Scale), PANSS (Positive and Negative Syndrome Scale), GAF (Global Assessment of Functioning). It was found that the quality of life was significantly lower in males, subjects who were divorced or widowed, living with parents, with worse living conditions and worse financial situation, financially dependent, with shorter period of time after last hospitalization, longer total period of time spent in hospital, lower GAF score, higher PANSS score, suicide attempt in the past, comorbid depressive and anxiety disorder, negative attitude of their families towards them and their treatment, and not-attending psychoeducation activities. It is crucial to treat the comorbid depressive and anxiety disorders in patients with schizophrenia due to the correlation between the serverity of those symptoms and the quality of life. The work policy should provide employment for patients in a stable psychic state, because patients who are unemployed and thus financially dependent declare a worse quality of life compared to those who are professionally active.