RESEARCH PAPER
The impact of gestational diabetes on changes in the concentration of selected hormones
regulating food intake in umbilical cord blood, and the development of obesity in children in later life
1
Department of Mother and Child Health, University of Medical Sciences, Poznań, Poland
2
Department of Medicine, President Stanisław Wojciechowski State University of Applied Sciences, Kalisz, Poland
3
Department of Animal Physiology, Biochemistry and Biostructure, University of Life Sciences, Poznań Poland
4
Students’ Scientific Society, President Stanisław Wojciechowski State University of Applied Sciences, Kalisz, Poland
5
Collegium Medicum, Institute of Health Sciences, University of Zielona Góra, Poland
6
Department of Anaesthesiology and Intensive Care, Hospital of the Ministry of the Internal Affairs and Administration,
Poznań, Poland
Corresponding author
Paweł A Kołodziejski
Department of Animal Physiology, Biochemistry and Biostructure, University of Life Sciences, Poznań, Poland
Department of Animal Physiology, Biochemistry and Biostructure, University of Life Sciences, Poznań, Poland
J Pre Clin Clin Res. 2023;17(3):149-156
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
Gestational diabetes mellitus (GDM) is a metabolic disease affecting an increasing number of women. The disease not only affects the health of mothers, but may also contribute to metabolic problems in children, both at the stage of foetal life and in the future, including increasing the risk of obesity or type 2 diabetes. Therefore, it is important to conduct research to get closer to fully defining the problem and developing therapies or methods of preventing GDM
Material and methods:
The study used umbilical cord blood from 540 women (260- healthy and 280 – GDM) and commercially available ELISA and RIA tests to investigate the interaction between leptin, ghrelin (active and total) and insulin in cord blood, and its correlation with anthropometric parameters of newborns as well as pregnancy week on the day of delivery, weight, BMI and growth of mothers.
Results:
It was found that in healthy mothers there were statistically significant correlations between maternal pre-pregnancy weight in relation to leptin (positive) and glucose (negative), a positive correlation between active ghrelin concentration and gestational week at delivery, and a positive level of leptin to the chest circumference of newborns, and a negative of glucose levels to the chest circumference of newborns at birth in the healthy group. In the GDM group, a positive correlation was found of total ghrelin to the abdominal circumference of the newborns at birth, and a positive of leptin concentration and thigh circumference of the newborns
Conclusions:
It was concluded that altered hormonal profiles during the prenatal period may have long-term consequences for the health of children. The study also indicated the need for further research in this area to better understand the causes and consequences of GDM r.
Gestational diabetes mellitus (GDM) is a metabolic disease affecting an increasing number of women. The disease not only affects the health of mothers, but may also contribute to metabolic problems in children, both at the stage of foetal life and in the future, including increasing the risk of obesity or type 2 diabetes. Therefore, it is important to conduct research to get closer to fully defining the problem and developing therapies or methods of preventing GDM
Material and methods:
The study used umbilical cord blood from 540 women (260- healthy and 280 – GDM) and commercially available ELISA and RIA tests to investigate the interaction between leptin, ghrelin (active and total) and insulin in cord blood, and its correlation with anthropometric parameters of newborns as well as pregnancy week on the day of delivery, weight, BMI and growth of mothers.
Results:
It was found that in healthy mothers there were statistically significant correlations between maternal pre-pregnancy weight in relation to leptin (positive) and glucose (negative), a positive correlation between active ghrelin concentration and gestational week at delivery, and a positive level of leptin to the chest circumference of newborns, and a negative of glucose levels to the chest circumference of newborns at birth in the healthy group. In the GDM group, a positive correlation was found of total ghrelin to the abdominal circumference of the newborns at birth, and a positive of leptin concentration and thigh circumference of the newborns
Conclusions:
It was concluded that altered hormonal profiles during the prenatal period may have long-term consequences for the health of children. The study also indicated the need for further research in this area to better understand the causes and consequences of GDM r.
Wojciechowska M, Chęcińska-Maciejewska Z, Pruszyńska-Oszmałek E, Ciborek A, Gibas-Dorna M, Rękas-Dudziak A, Krauss H, Kołodziejski PA.
The impact of gestational diabetes on changes in the concentration of selected hormones regulating food intake in umbilical cord blood,
and the development of obesity in children in later life. J Pre-Clin Clin Res. 2023; 17(3): 149–156. doi: 10.26444/jpccr/172938
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