REVIEW PAPER
The course of COVID-19 in pediatric patients – specific and non-specific clinical manifestations
1
Chair and Department of Forensic Medicine, Medical University, Lublin, Poland
2
Department of Plastic, Reconstructive and Burn Surgery, Poland
3
Department of Correct, Clinical and Imaging Anatomy, Chair of Fundamental Sciences, Medical University of Lublin,
Lublin, Poland
4
University Clinical Centre, Medical University, Warsaw, Poland
5
Department of Gynecology and Obstetrics, Independent Public Health Care Centre, Puławy, Poland
Corresponding author
Alicja Forma
Chair and Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b, 20-090, Lublin, Poland
Chair and Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b, 20-090, Lublin, Poland
J Pre Clin Clin Res. 2023;17(4):262-271
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
COVID-19 caused by SARS-CoV 2 is a still serious danger. The disease which triggered off the COVID-19 pandemic and one of the biggest health crises in many years, began in the city of Wuhan, China, in 2019. The aimof this review is to distinguish most of the specific and non-specific manifestations of the disease among children
Review methods:
The literature review was based on different types of articles including reviews, meta-analyses, systemic reviews, and randomized controlled trials on PubMed, Web of Science, and Scopus databases. Key words featured COVID-19, MIS-C, SARS-CoV-2 manifestations, and specific, and non-specific manifestations of COVID-19. The literature search was performed until September 2023, and concerned only paediatric patients.
Brief description of the state of knowledge:
Research based on already published studies prevents the forming of firm conclusions. There are different symptoms of COVID-19 infection, some of them are typical, mild, and do not concern medical care units. There are also some non-specific manifestations, often related to multisystem inflammatory syndrome in children (MIS-C), which are more severe and sometimes demand involving intensive care units.
Conclusions:
A large group of infected children with asymptomatic or present mild symptoms of COVID-19. Non- specific manifestations, such as cardiovascular, gastrointestinal, psychiatric, neurological, ophthalmic, dermatological, or rheumatological symptoms, can potentially be misleading and require more attention.
COVID-19 caused by SARS-CoV 2 is a still serious danger. The disease which triggered off the COVID-19 pandemic and one of the biggest health crises in many years, began in the city of Wuhan, China, in 2019. The aimof this review is to distinguish most of the specific and non-specific manifestations of the disease among children
Review methods:
The literature review was based on different types of articles including reviews, meta-analyses, systemic reviews, and randomized controlled trials on PubMed, Web of Science, and Scopus databases. Key words featured COVID-19, MIS-C, SARS-CoV-2 manifestations, and specific, and non-specific manifestations of COVID-19. The literature search was performed until September 2023, and concerned only paediatric patients.
Brief description of the state of knowledge:
Research based on already published studies prevents the forming of firm conclusions. There are different symptoms of COVID-19 infection, some of them are typical, mild, and do not concern medical care units. There are also some non-specific manifestations, often related to multisystem inflammatory syndrome in children (MIS-C), which are more severe and sometimes demand involving intensive care units.
Conclusions:
A large group of infected children with asymptomatic or present mild symptoms of COVID-19. Non- specific manifestations, such as cardiovascular, gastrointestinal, psychiatric, neurological, ophthalmic, dermatological, or rheumatological symptoms, can potentially be misleading and require more attention.
Januszewski J, Tobiasz M, Tyczyńska M, Forma A, Kłodnicka K, Zembala J, Turkosz A, Baj J. The course of COVID-19 in paediatric patients –
specific and non-specific clinical manifestations. J Pre-Clin Clin Res. 2023; 17(4): 262–271. doi:10.26444/jpccr/176957
REFERENCES (129)
1.
Mohamadian M, Chiti H, Shoghli A, et al. COVID-19: Virology, biology and novel laboratory diagnosis. J Gene Med. 2021 Feb;23(2):e3303. doi:10.1002/jgm.3303.
2.
Umakanthan S, Sahu P, Ranade AV, et al. Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19). Postgrad Med J. 2020 Dec;96(1142):753–758. doi:10.1136/ postgradmedj-2020-138234.
3.
Hu B, Guo H, Zhou P, et al. Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol. 2021 Mar; 19(3):141–154. doi:10.1038/s41579-020-00459-7.
4.
Atzrodt CL, Maknojia I, McCarthy RDP, et al. A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2. FEBS J. 2020 Sep; 287(17):3633–3650. doi:10.1111/febs.15375.
5.
Iranmanesh B, Khalili M, Amiri R, et al. Oral manifestations of COVID-19 disease: A review article. Dermatol Ther. 2021 Jan; 34(1):e14578. doi:10.1111/dth.14578.
6.
Kariyawasam JC, Jayarajah U, Riza R, et al. Gastrointestinal manifestations in COVID-19. Trans R Soc Trop Med Hyg. 2021 Dec 2;115(12):1362–1388. doi:10.1093/trstmh/trab042.
7.
Zhong Y, Wang K, Zhu Y, et al. Ocular manifestations in COVID-19 patients: A systematic review and meta-analysis. Travel Med Infect Dis. 2021 Nov-Dec;44:102191. doi:10.1016/j.tmaid.2021.102191.
8.
Juchnowicz D, Baj J, Forma A, et al. The Outbreak of SARS-CoV-2 Pandemic and the Well-Being of Polish Students: The Risk Factors of the Emotional Distress during COVID-19 Lockdown. J Clin Med. 2021 Mar 1;10(5):944. doi:10.3390/jcm10050944.
9.
Baj J, Forma A, Teresińska B, et al. How Does SARS-CoV-2 Affect Our Eyes-What Have We Learnt So Far about the Ophthalmic Manifestations of COVID-19? J Clin Med. 2022 Jun; 13;11(12): 3379. doi: 10.3390/jcm11123379.
10.
Khan M, Adil SF, Alkhathlan HZ, et al. COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far. Molecules. 2020 Dec 23;26(1):39. doi:10.3390/molecules26010039.
11.
Yesudhas D, Srivastava A, Gromiha MM. COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics. Infection. 2021 Apr;49(2):199–213. doi:10.1007/s15010-020-01516-2.
12.
Beyerstedt S, Casaro EB, Rangel ÉB. COVID-19: angiotensin- converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. Eur J Clin Microbiol Infect Dis. 2021 May; 40(5):905–919. doi:10.1007/s10096-020-04138-6.
13.
Ge ZY, Yang LM, Xia JJ, et al. Possible aerosol transmission of COVID-19 and special precautions in dentistry. J Zhejiang Univ Sci B. 2020 May;21(5): 361–368. doi:10.1631/jzus.B2010010.
14.
Salian VS, Wright JA, Vedell PT, et al. COVID-19 Transmission, Current Treatment, and Future Therapeutic Strategies. Mol Pharm. 2021 Mar 1;18(3):754–771. doi:10.1021/acs.molpharmaceut.0c00608.
15.
Jayaweera M, Perera H, Gunawardana B, et al. Transmission of COVID-19 virus by droplets and aerosols: A critical review on the unresolved dichotomy. Environ Res. 2020 Sep; 188:109819. doi:10.1016/j. envres.2020.109819.
16.
Geng Y, Wang Y. Stability and transmissibility of SARS-CoV-2 in the environment. J Med Virol. 2023 Jan; 95(1):e28103. doi:10.1002/jmv.28103.
17.
Rahman S, Montero MTV, Rowe K, et al. Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence. Expert Rev Clin Pharmacol. 2021 May; 14(5): 601–621. doi: 10.1080/17512433.2021.1902303.
18.
Li MY, Li L, Zhang Y, et al. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infect Dis Poverty. 2020 Apr 28; 9(1): 45. doi: 10.1186/s40249-020-00662-x.
19.
Tabatabaeizadeh SA. Airborne transmission of COVID-19 and the role of face mask to prevent it: a systematic review and meta-analysis. Eur J Med Res. 2021 Jan 2; 26(1): 1. doi:10.1186/s40001-020-00475-6.
20.
Borak J. Airborne Transmission of COVID-19. Occup Med (Lond). 2020 Jul 17; 70(5): 297–299. doi:10.1093/occmed/kqaa080.
21.
Zhao X, Liu S, Yin Y, et al. Airborne transmission of COVID-19 virus in enclosed spaces: An overview of research methods. Indoor Air. 2022 Jun; 32(6): e13056. doi: 10.1111/ina.13056.
22.
Domingo JL, Marquès M, Rovira J. Influence of airborne transmission of SARS-CoV-2 on COVID-19 pandemic. A review. Environ Res. 2020 Sep; 188: 109861. doi: 10.1016/j.envres.2020.109861.
23.
Karia R, Gupta I, Khandait H, et al. COVID-19 and its Modes of Transmission. SN Compr Clin Med. 2020; 2(10): 1798–1801. doi: 10.1007/s42399-020-00498-4.
24.
Abney SE, Bright KR, McKinney J, et al. Toilet hygiene-review and research needs. J Appl Microbiol. 2021 Dec; 131(6): 2705–2714. doi: 10.1111/jam.15121.
25.
Onakpoya IJ, Heneghan CJ, Spencer EA, et al. SARS-CoV-2 and the role of fomite transmission: a systematic review. F1000Res. 2021 Mar 24; 10: 233. doi: 10.12688/f1000research.51590.3.
26.
Arienzo A, Gallo V, Tomassetti F, et al. A narrative review of alternative transmission routes of COVID 19: what we know so far. Pathog Glob Health. 2023 Jun; 23: 1–15. doi: 10.1080/20477724.2023.2228048.
27.
Mourmouris P, Tzelves L, Roidi C, et al. COVID-19 transmission: a rapid systematic review of current knowledge. Osong Public Health Res Perspect. 2021 Apr; 12(2): 54–63. doi: 10.24171/j. phrp.2021.12.2.02
28.
Jamieson DJ, Rasmussen SA. An update on COVID-19 and pregnancy. Am J Obstet Gynecol. 2022 Feb; 226(2): 177–186. doi: 10.1016/j.ajog.2021.08.054.
29.
Rasmussen SA, Jamieson DJ. COVID-19 and Pregnancy. Infect Dis Clin North Am. 2022 Jun; 36(2): 423–433. doi: 10.1016/j.idc.2022.01.002.
30.
Moore KM, Suthar MS. Comprehensive analysis of COVID-19 during pregnancy. Biochem Biophys Res Commun. 2021 Jan 29; 538: 180–186. doi: 10.1016/j.bbrc.2020.12.064.
31.
Facciolà A, Micali C, Visalli G, et al. COVID-19 and pregnancy: clinical outcomes and scientific evidence about vaccination. Eur Rev Med Pharmacol Sci. 2022 Apr; 26(7): 2610–2626. doi: 10.26355/ eurrev_202204_28499.
32.
Abdollahpour S, Badiee Aval S, Khadivzadeh T. Do Not Neglect the Covid-19 Transmission Through Sexual Intercourse. J Sex Marital Ther. 2021; 47(7): 731–737. doi: 10.1080/0092623X.2021.1938765.
33.
Cipriano M, Giacalone A, Ruberti E. Sexual Behaviors During COVID-19: The Potential Risk of Transmission. Arch Sex Behav. 2020 Jul; 49(5): 1431–1432. doi: 10.1007/s10508-020-01757-0.
34.
Tatu AL, Nadasdy T, Nwabudike LC. Observations about sexual and other routes of SARS-CoV-2 (COVID-19) transmission and its prevention. Clin Exp Dermatol. 2020 Aug; 45(6): 761–762. doi: 10.1111/ ced.14274.
35.
Talic S, Shah S, Wild H, et al. Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-analysis. BMJ. 2021 Nov 17; 375: e068302. doi: 10.1136/bmj-2021–068302.
36.
Chen F, Tian Y, Zhang L, et al. The role of children in household transmission of COVID-19: a systematic review and meta-analysis. Int J Infect Dis. 2022 Sep; 122: 266–275. doi: 10.1016/j.ijid.2022.05.016.
37.
Williams PCM, Howard-Jones AR, Hsu P, et al. SARS-CoV-2 in children: spectrum of disease, transmission and immunopathological underpinnings. Pathology. 2020 Dec; 52(7): 801–808. doi: 10.1016/j. pathol.2020.08.001.
38.
Cui X, Zhao Z, Zhang T, et al. A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19). J Med Virol. 2021 Feb; 93(2): 1057–1069. doi: 10.1002/jmv.26398.
39.
Nikolopoulou GB, Maltezou HC. COVID-19 in Children: Where do we Stand? Arch Med Res. 2022 Jan; 53(1): 1–8. doi: 10.1016/j. arcmed.2021.07.002.
40.
Deville JD, Song E, Ouellette CP, et al. COVID-19: Clinical manifestations and diagnosis in children https://www.uptodate.com/ contents/covid-19-clinical-manifestations-and-diagnosis-in-children (accessed on September 2023).
41.
Toba N, Gupta S, Ali AY, et al. COVID-19 under 19: A meta-analysis. Pediatr Pulmonol. 2021 Jun; 56(6): 1332–1341. doi: 10.1002/ppul.25312.
42.
Hoste L, Van Paemel R, Haerynck F. Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. Eur J Pediatr. 2021 Jul; 180(7): 2019–2034. doi: 10.1007/s00431–021–03993–5.
43.
Yasuhara J, Kuno T, Takagi H, et al. Clinical characteristics of COVID-19 in children: A systematic review. Pediatr Pulmonol. 2020 Oct; 55(10): 2565–2575. doi: 10.1002/ppul.24991.
44.
Meena J, Yadav J, Saini L, et al. Clinical Features and Outcome of SARS-CoV-2 Infection in Children: A Systematic Review and Meta-analysis. Indian Pediatr. 2020 Sep 15; 57(9): 820–826. doi: 10.1007/s13312–020–1961–0.
45.
Carlotti APCP, de Carvalho WB, Johnston C, et al. Update on the diagnosis and management of COVID-19 in pediatric patients. Clinics (Sao Paulo). 2020 Nov 30; 75: e2353. doi: 10.6061/clinics/2020/e2353.
46.
Rai P, Kumar BK, Deekshit VK, et al. Detection technologies and recent developments in the diagnosis of COVID-19 infection. Appl Microbiol Biotechnol. 2021 Jan; 105(2): 441–455. doi: 10.1007/s00253– 020–11061–5.
47.
Chaimayo C, Kaewnaphan B, Tanlieng N, et al. Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in Thailand. Virol J. 2020 Nov 13; 17(1): 177. doi: 10.1186/s12985–020–01452–5.
48.
Rostad CA, Chahroudi A, Mantus G, et al. Quantitative SARS-CoV-2 Serology in Children With Multisystem Inflammatory Syndrome (MIS-C). Pediatrics. 2020 Dec; 146(6): e2020018242. doi: 10.1542/ peds.2020–018242.
49.
Mirbeyk M, Saghazadeh A, Rezaei N. A systematic review of pregnant women with COVID-19 and their neonates. Arch Gynecol Obstet. 2021 Jul; 304(1): 5–38. doi: 10.1007/s00404–021–06049-z.
50.
Venn AMR, Schmidt JM, Mullan PC. Pediatric croup with COVID-19. Am J Emerg Med. 2021 May; 43: 287.e1–287.e3. doi: 10.1016/j. ajem.2020.09.034.
51.
Zhu F, Ang JY. COVID-19 Infection in Children: Diagnosis and Management. Curr Infect Dis Rep. 2022; 24(4): 51–62. doi: 10.1007/s11908–022–00779–0.
52.
Qi K, Zeng W, Ye M, et al. Clinical, laboratory, and imaging features of pediatric COVID-19: A systematic review and meta-analysis. Medicine (Baltimore). 2021 Apr 16; 100(15): e25230. doi: 10.1097/ MD.0000000000025230.
53.
Chams N, Chams S, Badran R, et al. COVID-19: A Multidisciplinary Review. Front Public Health. 2020 Jul 29; 8: 383. doi: 10.3389/ fpubh.2020.00383.
54.
Cao Y, Liu X, Xiong L, et al. Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: A systematic review and meta-analysis. J Med Virol. 2020 Sep; 92(9): 1449–1459. doi: 10.1002/ jmv.25822.
55.
Xu X, Yu C, Qu J, et al. Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2. Eur J Nucl Med Mol Imaging. 2020 May; 47(5): 1275–1280. doi: 10.1007/s00259–020–04735–9.
56.
Simsek Uzunoglu S, Akca H. Systematic Review: Clinical Symptoms and Laboratory and Radiology Findings in Children with COVID-19. Niger J Clin Pract. 2021 Sep; 24(9): 1259–1267. doi: 10.4103/njcp. njcp_577_20.
57.
Yasuhara J, Watanabe K, Takagi H, et al. COVID-19 and multisystem inflammatory syndrome in children: A systematic review and meta-analysis. Pediatr Pulmonol. 2021 May; 56(5): 837–848. doi: 10.1002/ ppul.25245.
58.
Khatami F, Saatchi M, Zadeh SST, et al. A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis. Sci Rep. 2020 Dec 28; 10(1): 22402. doi: 10.1038/s41598–020–80061–2.
59.
Vakili S, Savardashtaki A, Jamalnia S, et al. Laboratory Findings of COVID-19 Infection are Conflicting in Different Age Groups and Pregnant Women: A Literature Review. Arch Med Res. 2020 Oct; 51(7): 603–607. doi: 10.1016/j.arcmed.2020.06.007.
60.
Baj J, Karakuła-Juchnowicz H, Teresiński G, et al. COVID-19: Specific and Non-Specific Clinical Manifestations and Symptoms: The Current State of Knowledge. J Clin Med. 2020 Jun 5; 9(6): 1753. doi: 10.3390/ jcm9061753.
61.
Zhang G, Zhang J, Wang B, et al. Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a retrospective analysis. Respir Res. 2020 Mar 26; 21(1): 74. doi: 10.1186/s12931–020–01338–8.
62.
Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020 Jun; 109(6): 1088–1095. doi: 10.1111/apa.15270.
63.
Graff K, Smith C, Silveira L, et al. Risk Factors for Severe COVID-19 in Children. Pediatr Infect Dis J. 2021 Apr 1; 40(4): e137-e145. doi:10.1097/INF.0000000000003043.
64.
Cao J, Devaraj S. COVID-19 in Pediatrics: A Laboratory Perspective. J Appl Lab Med. 2020 Jul 1; 5(4): 824–828. doi: 10.1093/jal /jfaa065.
65.
Jiang L, Tang K, Levin M, et al. COVID-19 and multisystem inflammatory syndrome in children and adolescents. Lancet Infect Dis. 2020 Nov; 20(11): e276-e288. doi: 10.1016/S1473–3099(20)30651–4.
66.
Patel JM. Multisystem Inflammatory Syndrome in Children (MIS-C). Curr Allergy Asthma Rep. 2022 May; 22(5): 53–60. doi: 10.1007/s11882–022–01031–4.
67.
Sperotto F, Friedman KG, Son MBF, et al. Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach. Eur J Pediatr. 2021 Feb; 180(2): 307–322. doi: 10.1007/s00431–020–03766–6.
68.
Ahmed M, Advani S, Moreira A, et al. Multisystem inflammatory syndrome in children: A systematic review. EClinicalMedicine. 2020 Sep; 26: 100527. doi: 10.1016/j.eclinm.2020.100527.
69.
Radia T, Williams N, Agrawal P, et al. Multi-system inflammatory syndrome in children & adolescents (MIS-C): A systematic review of clinical features and presentation. Paediatr Respir Rev. 2021 Jun; 38: 51–57. doi: 10.1016/j.prrv.2020.08.001.
70.
Waseem M, Shariff MA, Tay ET, et al. Multisystem Inflammatory Syndrome in Children. J Emerg Med. 2022 Jan; 62(1): 28–37. doi: 10.1016/j.jemermed.2021.07.070.
71.
Liu K, Yu J, Song G. Global Myocardial Strain in Multisystem Inflammatory Syndrome in Children, Kawasaki Disease, and Healthy Children: A Network Meta-Analysis. Front Pediatr. 2022 Jun 27; 10: 848306. doi: 10.3389/fped.2022.848306.
72.
Santos MO, Gonçalves LC, Silva PAN, Met al. Multisystem inflammatory syndrome (MIS-C): a systematic review and meta- analysis of clinical characteristics, treatment, and outcomes. J Pediatr (Rio J). 2022 Jul-Aug; 98(4): 338–349. doi: 10.1016/j.jped.2021.08.006.
73.
Mahmoud S, El-Kalliny M, Kotby A, et al. Treatment of MIS-C in Children and Adolescents. Curr Pediatr Rep. 2022; 10(1): 1–10. doi:10.1007/s40124–021–00259–4.
74.
Wang Z, Zhao S, Tang Y, et al. Potentially effective drugs for the treatment of COVID-19 or MIS-C in children: a systematic review. Eur J Pediatr. 2022 May; 181(5): 2135–2146. doi: 10.1007/s00431–022–04388-w.
75.
Levy E, Stintzi A, Cohen A, et al. Critical appraisal of the mechanisms of gastrointestinal and hepatobiliary infection by COVID-19. Am J Physiol Gastrointest Liver Physiol. 2021 Aug 1; 321(2): G99-G112. doi: 10.1152/ajpgi.00106.2021.
76.
Pegoraro F, Trapani S, Indolfi G. Gastrointestinal, hepatic and pancreatic manifestations of COVID-19 in children. Clin Res Hepatol Gastroenterol. 2022 Apr; 46(4): 101818. doi: 10.1016/j.clinre.2021.101818.
77.
Fathema K, Hassan MN, Mazumder MW, et al. COVID 19 in Children: Gastrointestinal, Hepatobiliary and Pancreatic Manifestation. Mymensingh Med J. 2021 Apr; 30(2): 570–579.
78.
Villanueva Ch M, Faundez H R, Godoy M. Manifestaciones gastrointestinales y hepáticas de COVID-19 en niños [Gastrointestinal and hepatic manifestations of COVID-19 in children]. Rev Chil Pediatr. 2020 Aug; 91(4): 623–630. doi: 10.32641/rchped.vi91i4.2484.
79.
Cooper S, Tobar A, Konen O, et al. Long COVID-19 Liver Manifestation in Children. J Pediatr Gastroenterol Nutr. 2022 Sep 1; 75(3): 244–251. doi: 10.1097/MPG.0000000000003521.
80.
Sica R, Pennoni S, Penta L, et al. Gastrointestinal and hepatic involvement during COVID-19 pandemic: A focus on pediatric population and possible future implications. World J Gastroenterol. 2021 Oct 28; 27(40): 7000–7004. doi: 10.3748/wjg.v27.i40.7000.
81.
Sica R, Pennoni S, Penta L, et al. New Onset of Hepatic Steatosis Post- Severe Multisystem Inflammatory Syndrome in Children (MIS-C): A Case Report. Int J Environ Res Public Health. 2021.
82.
Pousa PA, Mendonça TSC, Oliveira EA, et al. Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations. J Pediatr (Rio J). 2021 Mar- Apr; 97(2): 116–139. doi: 10.1016/j.jped.2020.08.007.
83.
Mao L, Jin H, Wang M, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in wuhan, China. JAMA Neurol. 2020; 77: 683–690.
84.
LaRovere KL, Riggs BJ, Poussaint TY, et al. Neurologic involvement in children and adolescents hospitalized in the United States for COVID-19 or multisystem inflammatory syndrome. JAMA Neurol. 2021; 78: 536–547.
85.
Púa Torrejón RC, Ordoño Saiz MV, González Alguacil E, et al. Smell and Taste Dysfunction in Pediatric Patients With SARS-CoV-2 Infection. Pediatr Neurol. 2022 Nov; 136: 28–33. doi: 10.1016/j. pediatrneurol.2022.07.006.
86.
Namazova-Baranova L, Karkashadze G, Zelenkova I, et al. A non- randomized comparative study of olfactory and gustatory functions in children who recovered from COVID-19 (1-year follow-up). Front Pediatr. 2022 Sep 9; 10: 919061. doi: 10.3389/fped.2022.919061.
87.
Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181: 271–280. e278.
88.
Cho SM, White N, Premraj L, et al; ISARIC Clinical Characterisation Group. Neurological manifestations of COVID-19 in adults and children. Brain. 2022 Sep; 10:awac332. doi: 10.1093/brain/awac332.
89.
Lin JE, Asfour A, Sewell TB, et al. Neurological issues in children with COVID-19. Neurosci Lett. 2021 Jan 19; 743: 135567. doi: 10.1016/j. neulet.2020.135567.
90.
Ray STJ, Abdel-Mannan O, Sa M, et al. Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study. Lancet Child Adolesc Health. 2021 Sep; 5(9): 631–641. doi: 10.1016/S2352–4642(21)00193–0.
91.
Decio A, Mazza A, Quadri V, et al. Neurological Manifestations of COVID-19 in Children: A Case of Facial Nerve Palsy. Pediatr Neurol. 2021 Mar; 116: 59. doi: 10.1016/j.pediatrneurol.2020.12.006.
92.
Kaur H, Mason JA, Bajracharya M, et al. Transverse Myelitis in a Child With COVID-19. Pediatr Neurol. 2020 Nov; 112: 5–6. doi: 10.1016/j. pediatrneurol.2020.07.017.
93.
Lavery MJ, Bouvier CA, Thompson B. Cutaneous manifestations of COVID-19 in children (and adults): A virus that does not discriminate. Clin Dermatol. 2021 Mar-Apr; 39(2): 323–328. doi: 10.1016/j. clindermatol.2020.10.020.
94.
Ciechanowicz P, Dopytalska K, Szczerba M, et al. Dermatological manifestations of the Coronavirus disease 2019 in children: a systemic review. Postepy Dermatol Alergol. 2022 Jun; 39(3): 491–508. doi: 10.5114/ada.2020.99294.
95.
Andina D, Belloni-Fortina A, Bodemer C, Bet al. Skin manifestations of COVID-19 in children: Part 1. Clin Exp Dermatol. 2021 Apr; 46(3): 444–450. doi: 10.1111/ced.14481.
96.
Andina D, Belloni-Fortina A, Bodemer C, et al. Skin manifestations of COVID-19 in children: Part 2. Clin Exp Dermatol. 2021 Apr; 46(3):451–461. doi: 10.1111/ced.14482.
97.
Andina D, Belloni-Fortina A, Bodemer C, et al. Skin manifestations of COVID-19 in children: Part 3. Clin Exp Dermatol. 2021 Apr; 46(3): 462–472. doi: 10.1111/ced.14483.
98.
Panda M, Agarwal A, Hassanandani T. Dermatological Manifestations of COVID-19 in Children. Indian Pediatr. 2022 May 15; 59(5): 393–399. doi: 10.1007/s13312–022–2521–6.
99.
Brumfiel CM, DiLorenzo AM, Petronic-Rosic VM. Dermatologic manifestations of COVID-19-associated multisystem inflammatory syndrome in children. Clin Dermatol. 2021 Mar-Apr; 39(2): 329–333. doi: 10.1016/j.clindermatol.2020.10.021.
100.
Rogers JP, Watson CJ, Badenoch J, et al. Neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives. J Neurol Neurosurg Psychiatry. 2021 Sep; 92(9): 932–941. doi: 10.1136/jnnp-2021–326405.
101.
Zawilska JB, Kuczyńska K. Psychiatric and neurological complications of long COVID. J Psychiatr Res. 2022 Dec; 156: 349–360. doi: 10.1016/j.jpsychires.2022.10.045.
102.
Singh S, Roy D, Sinha K, et al. Impact of COVID-19 and lockdown on mental health of children and adolescents: A narrative review with recommendations. Psychiatry Res. 2020 Nov; 293: 113429. doi: 10.1016/j.psychres.2020.113429.
103.
Markiewicz-Gospodarek A, Górska A, Markiewicz R, et al. The Relationship between Mental Disorders and the COVID-19 Pandemic—Course, Risk Factors, and Potential Consequences. Int. J. Environ. Res. Public Health 2022; 19: 9573. https://doi.org/10.3390/ ijerph19159573.
104.
Sitarz R, Forma A, Karakuła K, et al. How Do Polish Students Manage Emotional Distress during the COVID-19 Lockdown? A Web-Based Cross-Sectional Study. J. Clin. Med. 2021; 10: 4964. https://doi. org/10.3390/jcm10214964.
105.
Karakuła KH, Nowacka O, Ryczkowski A, et al. “COVID-19-induced psychosis: two case reports and narrative literature review” Curr. Prob. of Psych. 2022; vol.23, no.3, 3922: pp.151–158. https://doi.org/10.2478/ cpp-2022–0015.
106.
Sen M, Honavar SG, Sharma N, et al. COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19. Indian J Ophthalmol. 2021 Mar; 69(3): 488–509. doi: 10.4103/ijo.IJO_297_21.
107.
Danthuluri V, Grant MB. Update and Recommendations for Ocular Manifestations of COVID-19 in Adults and Children: A Narrative Review. Ophthalmol Ther. 2020 Dec; 9(4): 853–875. doi: 10.1007/ s40123–020–00310–5.
108.
Al-Namaeh M. Ocular manifestations of COVID-19. Ther Adv Ophthalmol. 2022 Apr 12; 14: 25158414221083374. doi: 10.1177/25158414221083374.
109.
Öztürk C, Yüce Sezen A, Savaş Şen Z, et al. Bilateral Acute Anterior Uveitis and Corneal Punctate Epitheliopathy in Children Diagnosed with Multisystem Inflammatory Syndrome Secondary to COVID-19. Ocul Immunol Inflamm. 2021 May 19; 29(4): 700–704. doi:10.1080/09273948.2021.1909070.
110.
Ichhpujani P, Singh RB, Dhillon HK et al. Ocular manifestations of COVID-19 in pediatric patients. Ther Adv Ophthalmol. 2023 Mar 14; 15: 25158414221149916. doi: 10.1177/25158414221149916.
111.
Ma N, Li P, Wang X, et al. Ocular Manifestations and Clinical Characteristics of Children With Laboratory-Confirmed COVID-19 in Wuhan, China. JAMA Ophthalmol. 2020 Oct 1; 138(10): 1079–1086. doi: 10.1001/jamaophthalmol.2020.3690.
112.
Valente P, Iarossi G, Federici M, et al. Ocular manifestations and viral shedding in tears of pediatric patients with coronavirus disease 2019: a preliminary report. J AAPOS. 2020 Aug; 24(4): 212–215. doi: 10.1016/j.jaapos.2020.05.002.
113.
Wu EY, Campbell MJ. Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children (MIS-C) Following COVID-19 Curr Cardiol Rep. 2021 Oct 1; 23(11): 168. doi: 10.1007/s11886–021– 01602–3.
114.
Oragui CC. Cardiovascular Manifestations of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With COVID-19. Cureus. 2023 Jul 16; 15(7): e41950. doi: 10.7759/ cureus.41950.
115.
Campanello C, Mercuri C, Derchi M, et al. Cardiovascular Manifestations in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19 According to Age. Children (Basel). 2022 Apr 20; 9(5): 583. doi: 10.3390/children9050583.
116.
Jone PN, John A, Oster ME, et al. SARS-CoV-2 Infection and Associated Cardiovascular Manifestations and Complications in Children and Young Adults: A Scientific Statement From the American Heart Association. Circulation. 2022 May 10; 145(19): e1037-e1052. doi: 10.1161/CIR.0000000000001064.
117.
Valverde I, Singh Y, Sanchez-de-Toledo J, et al. Acute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europe. Circulation. 2021 Jan 5; 143(1): 21–32. doi: 10.1161/CIRCULATIONAHA.120.050065.
118.
Kabeerdoss J, Pilania RK, Karkhele R, et al. Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management. Rheumatol Int. 2021 Jan; 41(1): 19–32. doi: 10.1007/s00296–020–04749–4.
119.
Gawaz M, Scharf RE. COVID-19: Cardio-pulmonary and Vascular Manifestations. Hamostaseologie. 2021 Oct; 41(5): 347–348. doi: 10.1055/a-1370–0231.
120.
Song MK, Kwon B. Arrhythmia and COVID-19 in children. Clin Exp Pediatr. 2023 May; 66(5): 190–200. doi: 10.3345/cep.2023.00024.
121.
Yasuhara J, Watanabe K, Takagi H, et al. COVID-19 and multisystem inflammatory syndrome in children: A systematic review and meta-analysis. Pediatr Pulmonol. 2021 May; 56(5): 837–849. doi: 10.1002/ ppul.25245.
122.
Saed Aldien A, Ganesan GS, Wahbeh F, et al. Systemic Inflammation May Induce Cardiac Injury in COVID-19 Patients Including Children and Adolescents Without Underlying Cardiovascular Diseases: A Systematic Review. Cardiovasc Revasc Med. 2022 Feb; 35: 169–178. doi: 10.1016/j.carrev.2021.04.007.
123.
Ramani SL, Samet J, Franz CK, et al. Musculoskeletal involvement of COVID-19: review of imaging. Skeletal Radiol. 2021 Sep; 50(9):1763–1773. doi: 10.1007/s00256–021–03734–7.
124.
Ahmed S, Zimba O, Gasparyan AY. COVID-19 and the clinical course of rheumatic manifestations. Clin Rheumatol. 2021 Jul; 40(7): 2611– 2619. doi: 10.1007/s10067–021–05691-x.
125.
Ciaffi J, Meliconi R, Ruscitti P, et al. Rheumatic manifestations of COVID-19: a systematic review and meta-analysis. BMC Rheumatol. 2020 Oct 28; 4: 65. doi: 10.1186/s41927–020–00165–0.
126.
Migliorini F, Bell A, Vaishya R, et al. Reactive arthritis following COVID-19 current evidence, diagnosis, and management strategies. J Orthop Surg Res. 2023 Mar 15; 18(1): 205. doi: 10.1186/s13018–023– 03651–6.
127.
Ciaffi J, Vanni E, Mancarella L, et al. Post-Acute COVID-19 Joint Pain and New Onset of Rheumatic Musculoskeletal Diseases: A Systematic Review. Diagnostics (Basel). 2023 May 25; 13(11): 1850. doi: 10.3390/ diagnostics13111850.
128.
Shah S, Danda D, Kavadichanda C, et al. Autoimmune and rheumatic musculoskeletal diseases as a consequence of SARS-CoV-2 infection and its treatment. Rheumatol Int. 2020 Oct; 40(10): 1539–1554. doi: 10.1007/s00296–020–04639–9.
129.
Pal A, Roongta R, Mondal S, et al. Does post-COVID reactive arthritis exist? Experience of a tertiary care centre with a review of the literature. Reumatol Clin (Engl Ed). 2023 Feb; 19(2): 67–73. doi: 10.1016/j.reumae.2022.03.005.
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