RESEARCH PAPER
Sensitive and selective extraction-free spectrophotometric determination of quetiapine fumarate in pharmaceuticals using two sulphonthalein dyes
1
Department of Chemistry, Manasagangothri, University of Mysore, Mysore, India
Corresponding author
Kanakapura Basavaiah
Department of Chemistry, Manasagangothri, University of Mysore, Mysore-570 006, India.
Department of Chemistry, Manasagangothri, University of Mysore, Mysore-570 006, India.
J Pre Clin Clin Res. 2010;4(1):24-31
KEYWORDS
ABSTRACT
Two direct, simple, sensitive and rapid extraction-free spectrophotometric methods have been developed for the determination of quetiapine fumarate (QTF) in pure form and in its dosage forms. The methods are based on the
formation of ion-pair complex between the drug and two sulphonthalein acidic dyes, namely, bromophenol blue (method A) and thymol blue (method B), followed by the measurement of absorbance at 410 and 380 nm, respectively.
Conformity to Beer’s law enabled the assay of the drug in the range 1-20 and 1.5-30 μg mL-1 in method A and method B with apparent molar absorptivities of 2.97 × 104 and 1.97 × 104 L mol-1cm-1, respectively. The Sandell sensitivity values, limits of detection (LOD) and quantifi cation (LOQ) values have also been reported for both the methods. The stoichiometry of the reaction in both cases was accomplished adopting the limiting logarithmic method and was found to be 1:2 (drug:dye). The accuracy and precision of the methods were evaluated on intra-day and inter-day basis; the relative error (%RE) was ≤ 3.5% and the relative standard deviation (RSD) was < 3%. The methods were successfully applied to the determination of drug in tablets without interference by the common co-formulated substances. Statistical comparison of the results with the reference method showed good concurrence and indicated no signifi cant diff erence in accuracy and precision
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