REVIEW PAPER
MicroRNA-26a-5p: multiple functions, multiple possibilities – a mini-review
1
Students’ Scientific Association of Clinical Genetics, Department of Clinical Genetics, Medical College, University of Rzeszów, Poland
2
Department of Allergology and Cystic Fibrosis, Clinical Regional Hospital No. 2, Rzeszów, Poland
Corresponding author
Paweł Zapolnik
Students’ Scientific Association of Clinical Genetics, Department of Clinical Genetics, Medical College, University of Rzeszów, Kopisto 2a, 35-959, Rzeszów, Poland
Students’ Scientific Association of Clinical Genetics, Department of Clinical Genetics, Medical College, University of Rzeszów, Kopisto 2a, 35-959, Rzeszów, Poland
J Pre Clin Clin Res. 2020;14(4):130-133
KEYWORDS
TOPICS
ABSTRACT
Introduction:
MicroRNA are small RNA molecules about 22 nucleotides long that do not encode proteins. Their function is to change the expression of proteins by attaching to their mRNA. They participate in various biological processes and pathogenesis of many diseases, including cancer. MicroRNA-26a-5p (miR-26a-5p) takes part in developing many disease entities and may become a potential therapeutic agent.
Objective:
The article aims to present the current knowledge on miR-26a-5p and consider the possible therapeutic use of this molecule.
State of knowledge:
Many studies on cell lines and model organisms indicate the suppressive function of miR-26a-5p in such neoplasms as breast cancer, pancreatic cancer, prostate cancer, thyroid cancer, or acute myeloid leukemia. In turn, in osteosarcoma cells, miR-26a-5p has an oncogenic character. miR-26a-5p is also associated with other diseases. Many authors have shown that this molecule is related to such entities as rheumatoid arthritis, osteoarthritis, preeclampsia, myocardial injury, or diabetic nephropathy.
Understanding the functions of miR-26a-5p and its participation in human diseases’ pathogenesis gives the possibility of the therapeutic use of this molecule in the future. However, knowledge of this subject is still limited. Further research to assess the efficacy and safety of the therapeutic use of miR-26a-5p is mandatory.
MicroRNA are small RNA molecules about 22 nucleotides long that do not encode proteins. Their function is to change the expression of proteins by attaching to their mRNA. They participate in various biological processes and pathogenesis of many diseases, including cancer. MicroRNA-26a-5p (miR-26a-5p) takes part in developing many disease entities and may become a potential therapeutic agent.
Objective:
The article aims to present the current knowledge on miR-26a-5p and consider the possible therapeutic use of this molecule.
State of knowledge:
Many studies on cell lines and model organisms indicate the suppressive function of miR-26a-5p in such neoplasms as breast cancer, pancreatic cancer, prostate cancer, thyroid cancer, or acute myeloid leukemia. In turn, in osteosarcoma cells, miR-26a-5p has an oncogenic character. miR-26a-5p is also associated with other diseases. Many authors have shown that this molecule is related to such entities as rheumatoid arthritis, osteoarthritis, preeclampsia, myocardial injury, or diabetic nephropathy.
Understanding the functions of miR-26a-5p and its participation in human diseases’ pathogenesis gives the possibility of the therapeutic use of this molecule in the future. However, knowledge of this subject is still limited. Further research to assess the efficacy and safety of the therapeutic use of miR-26a-5p is mandatory.
ACKNOWLEDGEMENTS
The authors thank Karolina Szela for her help in collecting materials
Zapolnik P, Zapolnik B. MicroRNA-26a-5p: multiple functions, multiple possibilities- a mini-review. J Pre-Clin Clin Res. 2020; 14(4): 130–133.doi: 10.26444/jpccr/128009
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