RESEARCH PAPER
Isobolographic interaction between AO-294, an enantiomer of losigamone, and phenobarbital in the mouse model of maximal electroshock
1
Experimental Neuropathophysiology Unit, Department of Pathophysiology, Medical University, Lublin, Poland
Corresponding author
Kinga Borowicz
Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
Department of Pathophysiology, Medical University, Jaczewskiego 8, 20-090 Lublin, Poland.
J Pre Clin Clin Res. 2007;1(1):41-42
KEYWORDS
ABSTRACT
The objective of the present study was to determine the exact type of interaction between AO-294, the less active enantiomer of a novel antiepileptic drug losigamone and phenobarbital in the model of maximal electroshock-induced convulsions in mice. Isobolographic analysis of obtained data show that the 2 drugs interact additively when administered in proportions of 1:3 and 1:1. Antagonism was found at the dose ratio of 3:1. This may suggest that AO-294 is not a good candidate for 2-drug therapy with phenobarbital, especially when administered at relatively high doses.
REFERENCES (9)
1.
Borowicz KK, Małek R, Kimber-Trojnar Z, Sobieszek G: Isobolographic analysis of the interactions of losigamone, remacemide, zonisamide with conventional antiepileptic drugs in the maximal electroshock test in mice – preliminary report. Neurol Neurochir Pol 2003, 3, 35-36.
2.
Gąsior M, Ungard JT, Witkin JM: Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures. J Pharmacol Exp Ther 1999, 290, 1148-1156.
3.
Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Loiseau P, Perucca E: Progress report on new antiepileptic drugs: a summary of the 4th Eilat conference (EILAT IV). Epilepsy Res 1999, 34, 1-41.
4.
Jones FA, Davies JA: The anticonvulsant effects of the enantiomers of losigamone. Br J Pharmacol 1999, 128, 1223-1228.
5.
Dimpfel W, Chatterje SS, Noldner M, Ticku MK: Effects of the anticonvulsant losigamone and its isomers on GABA-receptor system. Epilepsia 1995, 36, 983-989.
6.
Litchfield JT, Wilcoxon F: A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 1949, 96, 99–113.
7.
Loewe S: The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 1953, 3, 285-290.
8.
Łuszczki JJ, Czuczwar SJ: Isobolographic characterization of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. Naunyn Schmiedeberg’s Arch Pharmacol 2005, 372, 41-54.
9.
Tallarida RJ, Stone DJ, Raffa RB: Efficient designs for studying synergistic drug combinations. Life Sci 1997, 61, 417–425.
Share
RELATED ARTICLE
| eISSN: | 1898-7516 |
| ISSN: | 1898-2395 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
