CASE REPORT
Is congenital toxoplasmosis still an important clinical problem?
 
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1
Medical University of Lublin
 
2
Umm Al-Qura university, Makkah, Kingdom of Saudi Arabia
 
3
Adventist Hansdale Hospital, Hindsale Illinois, USA
 
 
Corresponding author
Ali Joman Alghamdi   

Medical University of Lublin, leszczynskigo 15A/9, 20069 lublin, Poland
 
 
J Pre Clin Clin Res. 2017;11(2):167-170
 
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Congenital toxoplasmosis is one of the most common intrauterine inherited diseases. The risk and severity of infection depends on the time of transmission during pregnancy. The earlier the infection, the lower the risk of transmission but with serious estimated outcomes and vice versa.

Case Report:
A newborn with congenital toxoplasmosis was born to a mother who was seronegative at the beginning of pregnancy, and was not aware of toxoplasmosis risk factors during pregnancy. The newborn was born with features of small for gestational age and with intracranial calcification revealed in cranial ultrasonography, which emphasized the need for further investigations. Neonatal serological panel and cerebrospinal fluid analysis were both confirmative of congenital toxoplasmosis. Ophthalmological examination showed the typical whitish focus of retinochoroiditis which later led to a blindness in one eye. Additionally, hydrocephalus was progressing slowly until it became stable in 5 months.

Objective:
The aim of this study was to present the case of congenital toxoplasmosis in order to underline the lack of social awareness concerning risk factors in pregnant women. Thus, educational campaigns against the consumption of raw meat and unpasteurized milk while pregnant may prevent the recurrence of such cases. Moreover, proper washing of fruits and vegetables are advised in this respect.

 
REFERENCES (15)
1.
Mattos, C., Spegiorin, L., Meira, C., Silva, T., Ferreira, A., Nakashima, F., et al., (2011). Anti-Toxoplasma gondii antibodies in pregnant women and their newborn infants in the region of São José do Rio Preto, São Paulo, Brazil. Sao Paulo Medical Journal, 129(4), 261-266.
 
2.
Radoń-Pokracka, M., Piasecki, M., Lachowska, A., Baczkowski, S., Spaczyńska, J., Górecka, M., et al., (2017). Assessment of the implementation of the infectious diseases screening programmes among pregnant women in the Lesser Poland region and comparison with similar programmes conducted in other European Union countries. Ginekologia Polska, 88(3), 151-155.
 
3.
Milewska-Bobula, B., Lipka, B., Golas, E., Debski, R., Marczynska, M., Paul, M., et al.,(2015). Recommended management of toxoplasma gondi infection in pregnant women and their children. Przegl Epidemiol, 69(2), 291-298.
 
4.
Pomares, C., & Montoya, J. G. (2016). Laboratory Diagnosis of Congenital Toxoplasmosis. Journal of Clinical Microbiology, 54(10), 2448–2454.
 
5.
Wolf A, Cowen D, Paige B. 1939. Human toxoplasmosis: occurrence in infants as an encephalomyelitis verification by transmission to animals. Science 89:226 –227.
 
6.
Salamon, D., & Bulanda, M. (2014). Toxoplasma gondii and women of reproductive age: an analysis of data from the Chair of Microbiology, Jagiellonian University Medical College in Cracow1. Annals of Parasitology, 60(4), 291-296. Retrieved August 28, 4014.
 
7.
Gross, U., Lüder, C. G. K., Hendgen, V., Heeg, C., Sauer, I., Weidner, A., et al., (2000). Comparative Immunoglobulin G Antibody Profiles between Mother and Child (CGMC Test) for Early Diagnosis of Congenital Toxoplasmosis. Journal of Clinical Microbiology, 38(10), 3619– 3622.
 
8.
Vidigal, P.V.T., Santos, D.V.V., Castro, F.C., Couto, J.C., Vitor, R.W., & Brasileiro Filho, G. (2002). Prenatal toxoplasmosis diagnosis from amniotic fluid by PCR. Revista da Sociedade Brasileira de Medicina Tropical, 35(1), 1-6.
 
9.
Naghili, B., Abbasalizadeh, S., Tabrizi, S., Rajaii, M., Akramiyan, M., Alikhan, H., et al, (2017). Comparison of IIF, ELISA and IgG avidity tests for the detection of anti-Toxoplasma antibodies in single serum sample from pregnant women. Le Infezioni in Medicina, (1), 50-56.
 
10.
Stajner, T., Bobic, B., Klun, I., Nikolic, A., Srbljanovic, J., Uzelac, A., et al., (2016). Prenatal and Early Postnatal Diagnosis of Congenital Toxoplasmosis in a Setting With No Systematic Screening in Pregnancy. Medicine, 95(9).
 
11.
Nowakowska, D., Colón, I., Remington, J. S., Grigg, M., Golab, E., Wilczynski, J., & Sibley, L. D. (2006). Genotyping of Toxoplasma gondii by Multiplex PCR and Peptide- Based Serological Testing of Samples from Infants in Poland Diagnosed with Congenital Toxoplasmosis. Journal of Clinical Microbiology, 44(4), 1382–1389.
 
12.
Modrzejewska, M., Patalan, J., Kulik, U., & Czeszyńska, M. (2016). Ocular manifestation of congenital toxoplasmosis, clinical implication – case report. Polish Gynaecology, 87(03).
 
13.
Paquet, C., Yudin, M. H., Allen, V. M., Bouchard, C., Boucher, M., Caddy, S., et al., (2013). Toxoplasmosis in Pregnancy: Prevention, Screening, and Treatment. Journal of Obstetrics and Gynaecology Canada, 35(1), 78-79.
 
14.
Chumpitazi, B. F., Boussaid, A., Pelloux, H., Racinet, C., Bost, M., & Goullier- Fleuret, A. (1995). Diagnosis of congenital toxoplasmosis by immunoblotting and relationship with other methods. Journal of Clinical Microbiology, 33(6), 1479–1485.
 
15.
Maldonado, Y., & Read, J. (2017). Diagnosis, Treatment, and Prevention of Congenital Toxoplasm osis in the United States. Pediatrics, 139(2), e20163860.
 
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