REVIEW PAPER
Icariin as a new potential drug in Alzheimer disease treatment – a review
1
Students Scientific Society of Neurology, Medical University of Lublin, Poland
2
Department of Neurology, Medical University of Lublin, Poland
Corresponding author
Patryk Piotr Jasielski
Students Scientific Society of Neurology, Medical University of Lublin, Lublin, Poland
Students Scientific Society of Neurology, Medical University of Lublin, Lublin, Poland
J Pre Clin Clin Res. 2019;13(4):167-169
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Alzheimer disease (AD) is one of the best-known diseases. It is neurodegenerative disease characterized by gradual memory loss and dysfunction of behaviour. The pathogenesis of this disease is unclear. Icariin (ICA) is a flavonoid found in a Chinese medicinal herb. It is recognised for a wide range of biological and medical activities: anti-tumour and anti-inflammatory, and also has an impact on the nervous system: stimulates neuroproliferation and prevents neuron’s apoptosis. ICA may have a potential role in AD disease treatment.
Objective:
The purpose of this article is to review current knowledge about mechanisms and use of ICA in AD treatment.
State of knowledge:
AD does not present established pathomechanism, about which there are some hypotheses. Each hypothesis mentioned and checked in this review, with result that ICA may have a potential role. One well-known hypothesis is that about amylolytic which is associated with amyloid precursor protein (APP) gene mutation, which leads to amyloid beta (Aβ) protein accumulation and to occurenc of the disease. In this hypothesis, ICA may inhibit Aβ protein aggregation or alter APP expression. ICA may stifle neuronal apoptosis and promote neurogenesis and neuromodulation. According to other hypotheses, ICA could also impact on iron overload in the brain, harmful for neurons hyperhomocysteinaemia, disorder of the intracellular calcium management. Modification of theTau protein structure is another one theory of ICA action. Flavonoid from China may also have an influence on axonal transport.
Conclusions:
According to the literature there is no single mechanism of ICA action in slowing down AD progress. A wide range of therapeutic points is demonstrated by the broad effect of this substance. Further research is mandatory.
Alzheimer disease (AD) is one of the best-known diseases. It is neurodegenerative disease characterized by gradual memory loss and dysfunction of behaviour. The pathogenesis of this disease is unclear. Icariin (ICA) is a flavonoid found in a Chinese medicinal herb. It is recognised for a wide range of biological and medical activities: anti-tumour and anti-inflammatory, and also has an impact on the nervous system: stimulates neuroproliferation and prevents neuron’s apoptosis. ICA may have a potential role in AD disease treatment.
Objective:
The purpose of this article is to review current knowledge about mechanisms and use of ICA in AD treatment.
State of knowledge:
AD does not present established pathomechanism, about which there are some hypotheses. Each hypothesis mentioned and checked in this review, with result that ICA may have a potential role. One well-known hypothesis is that about amylolytic which is associated with amyloid precursor protein (APP) gene mutation, which leads to amyloid beta (Aβ) protein accumulation and to occurenc of the disease. In this hypothesis, ICA may inhibit Aβ protein aggregation or alter APP expression. ICA may stifle neuronal apoptosis and promote neurogenesis and neuromodulation. According to other hypotheses, ICA could also impact on iron overload in the brain, harmful for neurons hyperhomocysteinaemia, disorder of the intracellular calcium management. Modification of theTau protein structure is another one theory of ICA action. Flavonoid from China may also have an influence on axonal transport.
Conclusions:
According to the literature there is no single mechanism of ICA action in slowing down AD progress. A wide range of therapeutic points is demonstrated by the broad effect of this substance. Further research is mandatory.
REFERENCES (25)
1.
Gaweł M, Potulska-Chromik A. “Choroby neurodegeneracyjne: choroba Alzheimera i Parkinsona” Postępy Nauk Medycznych, 2015; XXVIII(7): 468–476.
2.
Sheng C, Xu P, Zhou K, Deng D, Zhang C, Wang Z. “Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1–42-Induced Rat Model of Alzheimer’s Disease”. Biomed Res Int. 2017; 7464872. doi: 10.1155/2017/7464872 2017; 2017: 7464872.
3.
Li F, Dong H. X, Gong Q. H, Wu Q, Jin F, Shi J. S. “Icariin decreases both APP and Aβ levels and increases neurogenesis in the brain of Tg2576 mice. “Neuroscience. 2015; 24; 304: 29–35. doi: 10.1016/j. neuroscience.2015.06.010.
4.
Liu J, Liu Z, Zhang Y, Yin F. “A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide”; Indian J Med Res. 2015: 142(2): 190–195.
5.
Chen Y. J, Zheng H. Y, Huang X. X, Han S. X, Zhang D. S, Ni J. Z. et al. “Neuroprotective Effects of Icariin on Brain Metabolism, Mitochondrial Functions, and Cognition in Triple-Transgenic Alzheimer’s Disease Mice. "CNS Neurosci Ther. 2016; 22(1): 63–73. doi: 10.1111/cns.12473.
6.
Zhang ZY, Li C, Zug C, Schluesener HJ. “Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis”. PLoS One. 2014; 9(8): e104616. doi: 10.1371/journal.pone.0104616.
7.
Zhang L, Shen C, Chu J, Zhang R, Li Y, Li L. “Icariin decreases the expression of APP and BACE-1 and reduces the β-amyloid burden in an APP transgenic mouse model of Alzheimer’s disease”. Int J Biol Sci. 2014; 10(2): 181–191. doi: 10.7150/ijbs.6232.
8.
Liu H, Xue X, Shi H, Qi L, Gong D. “Osthole upregulates bdnf to enhance adult hippocampal neurogenesis in APP/PS1 transgenic mice”. Biological & Pharmaceutical Bulletin 2015; 38(10): 1439–1449.
9.
Nakai N, Nagai T, Tanaka M, Itoh N, Asai N, Enomoto A, et al. “Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/ Akt signaling with NMDA receptor, "Journal of Neuroscience, 2014: 34(45): 14995–15008.
10.
Zhang D, Wang Z, Sheng C, Peng W, Hui S, Gong W, et al.” Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3K/Akt Pathway in PC-12 Cells”. Evid Based Complement Alternat Med. 2015: 235265. doi: 10.1155/2015/235265.
11.
Li L, Tsai HJ, Li L, Wang XM. “Icariin inhibits the increased inward calcium currents induced by amyloid-beta (25–35) peptide in CA1 pyramidal neurons of neonatal rat hippocampal slice.” Am J Chin Med. 2010; 38(1): 113–125.
12.
Nie J, Luo Y, Huang XN, Gong QH, Wu Q, Shi JS. “Icariin inhibits betaamyloid peptide segment 25–35 induced expression of beta-secretase in rat hippocampus. Eur J Pharmacol. 2010; 626(2–3): 213–218. doi: 10.1016/j.ejphar.2009.09.039.
13.
Cui, Z, Sheng Z, Yan X, Cao Z, Tang K. ”In silico insight into potential anti-alzheimer’s disease mechanisms of icariin” Int J Mol Sci. 2016; 17: 113. doi: 10.3390/ijms170100113.
14.
Chen YJ, Zheng HY, Huang XX, Han SX, Zhang DS, Ni JZ, et al. ”The protective effect of icariin on mitochondrial transport and distribution in primary hippocampal neurons from 3× Tg-AD mice” CNS Neurosci Ther. 2016; 22(1): 63–73. doi: 10.1111/cns.12473.
15.
Zong N, Li F, Deng Y, Shi J, Jin F, Gong Q. “Icariin, a major constituent from Epimedium brevicornum, attenuates ibotenic acid-induced excitotoxicity in rat hippocampus.” Behav Brain Res. 2016; 313: 111–119. doi: 10.1016/j.bbr.2016.06.055.
16.
Zhang Y, Kong WN, Chai XQ. “Compound of icariin, astragalus, and puerarin mitigates iron overload in the cerebral cortex of Alzheimer’s disease mice”, Neural Regeneration ResearchOpen Access. 2018; 13(4): 731–736.
17.
Dong XH, Gao WJ, Kong WN, et al. “Neuroprotective effect of the active components of three Chinese herbs on brain iron load in a mouse model of Alzheimer’s disease”. Exp Ther Med. 2015; 9(4): 1319–1327. doi: 10.3892/etm.2015.2234.
18.
Li XA, HO YS, Chen L, Hsiao WL. “The Protective Effects of Icariin against the Homocysteine-Induced Neurotoxicity in the Primary Embryonic Cultures of Rat Cortical Neurons”. Molecules. 2016; 21(11): 1557.
19.
Fu X, Li S, Zhou S, Wu Q, Jin F, Shi J. “Stimulatory effect of icariin on the proliferation of neural stem cells from rat hippocampus” BMC Complement Altern Med. 2018; 29; 18(1): 34. doi: 10.1186/s12906-018- 2095-y.
20.
Jin F, Gong QH, Xu YS, Wang LN, Jin H, Li F, et al. “Icariin, a phoshphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling” International Journal of Neuropsychopharmacology. 2014; 29(2): 871–881.
21.
Zhang Z, Zhang T, Dong K. “Icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels in the hippocampus of the senescence- accelerated mouse”. Neural Regen Res. 2012; 7(12): 885–890. doi: 10.3969/j.issn.1673-5374.2012.12.001.
22.
Li Y, Zhang XX, Jiang LJ, Yuan L, Cao TT, Li X, et al. “Inhibition of Acetylcholinesterase (AChE): A Potential Therapeutic Target to Treat Alzheimer’s Disease.” SFChem Biol Drug Des. 2015; 86(4): 776–82. doi: 10.1111/cbdd.12550.
23.
Chen FJ, Liu B, Wu Q, Liu J, Xu YY, Zhou SY, et al. “Icarin delays brain aging in senescence-accelerated mouse prone 8 (SAMP8) model via inhibiting autophagy”. JPET; 2019; 369(1): 121–128. doi: https://doi. org/10.1124/jpet.118.253310.
24.
Li F, Zhang Y, Lu X, Shi J, Gong Q. “Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress” Life Sciences. 2019; 234(1): 116739.
25.
Zhu T, Zhang F, Li H, He Y, Zhang G, Huang N, et al. “Long-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice”. Clin Interv Aging. 2019; 14: 817–826. doi: 10.2147/CIA.S208068.
| eISSN: | 1898-7516 |
| ISSN: | 1898-2395 |
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