CASE REPORT
Histamine intolerance caused by Diamine Oxidase (DAO) deficiency – case report
1
Student Research Group at the Department and Clinic of Gastroenterology with Endoscopy Laboratory, Medical University of Lublin, Poland
2
Department and Clinic of Gastroenterology with Endoscopy Laboratory, Medical University of Lublin, Poland
Corresponding author
Aleksandra Iwona Zimna
Student Research Group at the Department and Clinic of Gastroenterology with Endoscopy Laboratory, Medical University of Lublin, Jaczewskiego 8, 20-400, Lublin, Poland
Student Research Group at the Department and Clinic of Gastroenterology with Endoscopy Laboratory, Medical University of Lublin, Jaczewskiego 8, 20-400, Lublin, Poland
J Pre Clin Clin Res. 2022;16(3):81-84
KEYWORDS
TOPICS
ABSTRACT
Histamine is a biogenic amine, which occurs naturally in the human body. Histamine can be metabolised with Diamine
Oxidase (DAO) Enzyme. It is estimated that in 1% of people, as a result of an imbalance between the supply and degradation
of histamine, a condition called histamine intolerance (HIT) develops. The case report describes a 40-year-old women who
visited the Emergency Room several times due to quickly increasing face oedema, rush, chest pain and dyspnoea after
eating meals containing histamine. For many years, the patient has struggled with non-specific symptoms. The woman
decided to have a test performed to determine the enzymatic activity of DAO in the blood serum. The result was 5 U/ml,
which indicates a significant shortage of DAO. Taking into consideration the symptoms the patient presented, extensive
differential diagnosis, which excluded the presence of other diseases and serum DAO activity test, it was possible to diagnose
histamine intolerance caused by DAO deficiency
Zimna AI, Wróblewski H, Dubaj M, Dembowska A, Gawryś A, Skrzydło-Radomańska B. Histamine intolerance caused by Diamine Oxidase
(DAO) deficiency – case report. J Pre-Clin Clin Res. 2022; 16(3): 81–84. doi: 10.26444/jpccr/153097
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| eISSN: | 1898-7516 |
| ISSN: | 1898-2395 |
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