CASE REPORT
Distant metastases from the uterine leiomyoma – case report of a pulmonary benign metastasizing leiomyoma
1
Department of Clinical Interventional Sciences, Faculty of Medical Sciences and Health Sciences, Kazimierz Pułaski University, Radom, Poland
2
Student Scientific Association, Department of Gynaecologic Oncology, Maria Sklodowska-Curie National Institute of Oncology – National Research Institute, Warsaw., Poland
3
Gynaecologic Oncology Clinic, Maria Sklodowska-Curie National Institute of Oncology – National Research Institute, Warsaw, Poland
Corresponding author
Natalia Izabela Szczęsny
Department of Clinical Interventional Sciences, Faculty of Medical Sciences and Health Sciences, Casimir Pulaski Radom University,Radom, Poland
Department of Clinical Interventional Sciences, Faculty of Medical Sciences and Health Sciences, Casimir Pulaski Radom University,Radom, Poland
J Pre Clin Clin Res. 2024;18(3):213-217
KEYWORDS
TOPICS
ABSTRACT
Benign metastasizing leiomyoma (BML) is a rare condition predominantly affecting women of late reproductive age, characterized by metastasis of the uterine leiomyomas to distant organs. The case is presented of a 48-year-old woman with BML who initially presented with non-specific abdominal pain. She was diagnosed with a uterine tumour and multiple pulmonary metastases. Therefore, uterine sarcoma was suspected. However, pathologic examination of core needle biopsy of the uterine tumour revealed leiomyoma cells. Due to inconsistency between pathologic examination and imaging, hysterectomy was performed. The final pathologic diagnosis confirmed leiomyoma in the uterus. To exclude another malignancy, thoracotomy with open lung biopsy was performed. Histopathological examination showed the same cells as in the uterine leiomyoma, resulting in the diagnosis of BML. Gonadotropin-releasing hormone (GnRH) analog was administered. After 15 months, the patient remained stable without disease progression.
Szczęsny NI, Karoń K, Bornio E, Piątkowski K, Grabowski W, Plata H, Piątek Sz. Distant metastases from the uterine leiomyoma: a case report of a pulmonary benign metastasizing leiomyoma. J Pre-Clin Clin Res. 2024; 18(3): 213–217. doi: 10.26444/jpccr/190538
REFERENCES (26)
1.
Barnaś E, Książek M, Raś R, et al. Benign metastasizing leiomyoma: A review of current literature in respect to the time and type of previous gynecological surgery. PLoS One. 2017;12(4):e0175875. https://doi.org/10.1371/journa....
2.
Latos W, Kawczyk-Krupka A, Strzelczyk N, et al. Benign and non-neoplastic tumours of the duodenum. Prz Gastroenterol. 2019;14(4):233–241. https://doi.org/10.5114/pg.201....
3.
Raś R, Książek M, Barnaś E, et al. Benign metastasizing leiomyoma in triple location: lungs, parametria and appendix. Prz Menopauzalny. 2016;15(2):117–121. https://doi.org/10.5114/pm.201....
4.
Karnib M, Rhea I, Elliott R, et al. Benign Metastasizing Leiomyoma in the Heart of a 45-Year-Old Woman. Tex Heart Inst J. 2021;48(1):e197066. https://doi.org/10.14503/THIJ-....
5.
Awonuga AO, Shavell VI, Imudia AN, et al. Pathogenesis of benign metastasizing leiomyoma: a review. Obstet Gynecol Surv. 2010;65(3):189–195. https://doi.org/10.1097/ogx.0b....
6.
Hann M, Manacheril R, St Pierre J, et al. Recurrent pneumothoraces in a patient with pulmonary benign metastasizing leiomyoma. Ochsner J. 2017;17(3):284–287.
7.
Wojtyś ME, Kacalska-Janssen O, Ptaszyński K, et al. Benign Metastasizing Leiomyoma of the Lung: Diagnostic Process and Treatment Based on Three Case Reports and a Review of the Literature. Biomedicines. 2022;10(10):2465. https://doi.org/10.3390/biomed....
8.
Sawai Y, Shimizu T, Yamanaka Y, et al. Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review. Oncol Lett. 2017;14(3):3641–3646. https://doi.org/10.3892/ol.201....
9.
Jo HC, Baek JC. Case of pulmonary benign metastasizing leiomyoma from synchronous uterine leiomyoma in a postmenopausal woman. Gynecologic Oncology Reports. 2018;26:33–36. https://doi:10.1016/j.gore.201....
10.
Padhi P, Topalovski M. Benign Metastasizing Leiomyoma of the Uterus with Pulmonary and Bone Metastases. Case Rep Obstet Gynecol. 2021;2021:5536675. https://doi.org/10.1155/2021/5....
11.
Choe YH, Jeon SY, Lee YC, et al. Benign metastasizing leiomyoma presenting as multiple cystic pulmonary nodules: a case report. BMC Womens Health. 2017;17(1):81. https://doi.org/10.1186/s12905....
12.
Jautzke G, Müller-Ruchholtz E, Thalmann U. Immunohistological detection of estrogen and progesterone receptors in multiple and well differentiated leiomyomatous lung tumours in women with uterine leiomyomas (so-called benign metastasizing leiomyomas). A report on 5 cases. Pathol Res Pract. 1996;192(3):215–23. https://doi.org/10.1016/S0344-....
13.
Has Simsek D, Kuyumcu S, Ozkan ZG, et al. Demonstration of in vivo estrogen receptor status with 16α- [18F]fluoro-17ß-oestradiol (FES) PET/CT in a rare case of benign metastasizing leiomyoma. Eur J Nucl Med Mol Imaging. 2021 Nov;48(12):4101–4102. doi:10.1007/s00259-021-05410-3. Epub 2021 May 25. PMID: 34031720.
14.
Tong T, Fan Q, Wang Y, et al. Benign metastasizing uterine leiomyoma with lymphatic and pulmonary metastases: a case report and literature review. BMC Womens Health. 2023;23(1):154. https://doi.org/10.1186/s12905....
15.
Kitayama T, Tanaka T, Hiraki T, et al. Pulmonary lymphatic involvement in metastatic uterine sarcomas: imaging and pathological appearance. Radiol Case Rep. 2021;16(9):2460–2462. https://doi:10.1016/j.radcr.20....
16.
Tori M, Akamatsu H, Mizutani S, et al. Multiple benign metastasizing leiomyomas in the pelvic lymph nodes and biceps muscle: report of a case. Surg Today. 2008;38(5):432–435. https://doi:10.1007/s00595-007....
17.
Horiuchi K, Yabe H, Mukai M, et al. Multiple smooth muscle tumours arising in deep soft tissue of lower limbs with uterine leiomyomas. Am J Surg Pathol. 1998;22(7):897–901. https://doi:10.1097/00000478-1....
18.
Alessi G, Lemmerling M, Vereecken L, et al. Benign metastasizing leiomyoma to skull base and spine: a report of two cases. Clin Neurol Neurosurg. 2003;105(3):170–174. https://doi:10.1016/s0303-8467....
19.
Zong D, He W, Li J, et al. Concurrent benign metastasizing leiomyoma in the lung and lumbar spine with elevated standardized uptake value level in positron-emission tomography computed tomography: A case report and literature review. Medicine (Baltimore). 2018;97(27):e11334. https://doi:10.1097/MD.0000000....
20.
Findakly D, Wang J. Molecular Profiling of Benign Metastasizing Leiomyoma of the Uterus Revealing Unique Novel Therapeutic Targets. Cureus. 2020;12(4):e7701. https://doi:10.7759/cureus.770....
21.
2Rivera JA, Christopoulos S, Small D, et al. Hormonal manipulation of benign metastasizing leiomyomas: Report of two cases and review of the literature. J Clin Endocrinol Metab. 2004;89(7):3183–3188. https://doi.org/10.1210/jc.200....
22.
Matos F, Santiago C, Silva D. Multisystemic Benign Metastasizing Leiomyoma: An Unusual Condition with an Atypical Clinical Presentation. Case Reports in Radiology. 2019;2019:1–4. https://doi.org/10.1155/2019/7....
23.
Fu Y, Li H, Tian B, et al. Pulmonary benign metastasizing leiomyoma: a case report and review of the literature. World J Surg Oncol. 2012;10:268. https://doi:10.1186/1477-7819-....
24.
Raposo MI, Meireles C, Cardoso M, et al. Benign Metastasizing Leiomyoma of the Uterus: Rare Manifestation of a Frequent Pathology. Case Reports in Obstetrics and Gynecology. 2018;2018:1–8. https://doi.org/10.1155/2018/5....
25.
Ofori K, Fernandes H, Cummings M, et al. Benign metastasizing leiomyoma presenting with miliary pattern and fatal outcome: Case report with molecular analysis & review of the literature. Respiratory Medicine Case Reports. 2019;27:100831. https://doi.org/10.1016/j.rmcr....
26.
Usman M, Bakhtawar N, Rajni Sudhir R. Benign Metastasizing Leiomyoma (BML) – A Rare Phenomenon with even Rarer Radiology and Disease Course. J Pak Soc Intern Med. 2022;3(2):157–159.
| eISSN: | 1898-7516 |
| ISSN: | 1898-2395 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
