Determination of basic blood biochemical parameters are used as a measure taken in atherosclerosis prophylaxis, or is performed depending on the complications found in the course of the disease. The aim of the study was to find diff erences between basic biochemical parameters measured in blood serum of patients with atherosclerosis. The study comprised 52 men, who were divided into three groups depending upon the type of surgical procedure performed due to atherosclerosis on internal carotid artery, aortic – iliac section and femoral – popliteal section of the femoral artery. The serum concentration of C-reactive protein was determined with the use of the rocket immunoelectrophoresis method (RI). The levels of total cholesterol, its HDL and LDL fractions and triglycerides were measured by the immunoenzymatic method (ELISA). Fibrinogen level was determined according to Clauss’s and ELISA tests. Total cholesterol, HDL and LDL fractions and triglycerides remained within the norm. Performed biochemical examinations did not significantly differ between the analysed groups of patients. Collective analysis of the correlation coefficient between the analysed parameters showed that the serum triglyceride concentration decreases with the patients’ age. An increase in the acute phase protein concentration was accompanied by a decrease in the concentrations of total cholesterol, LDL and triglycerides. The above relationship was not found in the case of HDL fraction of cholesterol. The results show that the biochemical determinations performed in blood serum of patients with atherosclerosis are not dependent on the location of an obliterated vessel. The significant parameters in this analysis are the acute phase protein concentration (CRP) and the fibrinogen level.