REVIEW PAPER
Clinical application of AD-MSCs – A review
1
Polish Stem Cell Bank,Warsaw, Poland
2
Clinic of Paediatric Neurology, III Faculty of Paediatrics, Medical Univercity of Lublin
J Pre Clin Clin Res. 2018;12(3):100-105
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Mesenchymal stromal/stem cells (MSCs) are a unique type of stem cell which can be successfully used in regenerative medicine. They are safe, have the ‘stem cell’ ability of self-renewal and under appropriate conditions can differentiate into other types of cells without the problem of teratoma formation. MSCs express the characteristic phenotype (CD73ᶧ, CD90ᶧ, CD105ᶧ, CD14⁻, CD19⁻, CD34⁻, CD45⁻, HLA-DR⁻) and show immunosuppressive features, such as low expression of MHC I, lack of MHC II and secretion of a wide variety of immunoprotective cytokines and growth factors. One of the MSC sources is adipose tissue, which has some advantages compared with other existing sources. Currently, adipose tissue as a source of mesenchymal stromal/stem cells have become of interest due to a less invasive procedure of isolation and safety. This review contains data from various studies about the usage of adipose-derived MSCs in the treatment of different diseases.
Objectives:
The main aim of this review is evaluation of the useful characteristics of adipose-derived mesenchymal stem cells and their usage in stem cell treatment of some diseases. The aim is to describe the current knowledge and future perspectives.
Conclusions:
Adipose-derived MSCs (AD-MSCs) represent a good tool in regenerative stem cell therapy.
Mesenchymal stromal/stem cells (MSCs) are a unique type of stem cell which can be successfully used in regenerative medicine. They are safe, have the ‘stem cell’ ability of self-renewal and under appropriate conditions can differentiate into other types of cells without the problem of teratoma formation. MSCs express the characteristic phenotype (CD73ᶧ, CD90ᶧ, CD105ᶧ, CD14⁻, CD19⁻, CD34⁻, CD45⁻, HLA-DR⁻) and show immunosuppressive features, such as low expression of MHC I, lack of MHC II and secretion of a wide variety of immunoprotective cytokines and growth factors. One of the MSC sources is adipose tissue, which has some advantages compared with other existing sources. Currently, adipose tissue as a source of mesenchymal stromal/stem cells have become of interest due to a less invasive procedure of isolation and safety. This review contains data from various studies about the usage of adipose-derived MSCs in the treatment of different diseases.
Objectives:
The main aim of this review is evaluation of the useful characteristics of adipose-derived mesenchymal stem cells and their usage in stem cell treatment of some diseases. The aim is to describe the current knowledge and future perspectives.
Conclusions:
Adipose-derived MSCs (AD-MSCs) represent a good tool in regenerative stem cell therapy.
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