Chronic Fatigue Syndrome (CFS) is characterized by a chronic (lasting longer than 6 months) feeling of fatigue and a complex of other symptoms that include headache, muscle and joint aches, memory and concentration disorders, and others. Its etiology is not known. There are no objective methods for confirming the illness nor its causal treatment, which of course, makes the whole matter so. There are suggestions that CFS may be a result of chronic inflammation. In order to consider the potential existence of a causal link between CFS and infection, 48 farmers (everyone in the service region, after exclusions for cause) who suffered from neuroborreliosis were examined 6 months or later after the occurrence of disease. In this group, 37 (77%) presented a clinical picture of CFS. Furthermore, of these 37 people, the condition of 29 (78%) improved after receiving comprehensive symptomatic treatment for CFS. The results are twofold. First, all subjects with borreliosis showed one or more chronic fatigue syndrome attributes after the course of the disease, with 75% meeting all the CDC criteria for CFS. Second, the combined symptomatic treatment, on a patient-by-patient basis, for each manifested clinical CFS symptom, more than 75% demonstrated improvement.