RESEARCH PAPER
Cardiovascular risk factors in menopausal women and the intima-media thickness
 
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1
Department of Internal Disease, Medical University, Lublin, Poland
 
2
Department of Vascular Surgery and Angiology, Medical University, Lublin, Poland
 
 
Corresponding author
Piotr Terlecki   

Chair and Department of Vascular Surgery and Angiology, University School of Medicine, Jaczewskiego 8, 20-090 Lublin, Poland.
 
 
J Pre Clin Clin Res. 2009;3(1):61-63
 
KEYWORDS
ABSTRACT
The aim of this study was analysis of the relationship between cardiovascular risk factors and intima-media thickness (I-M) at menopause. 27 women aged 53.4±3.7 years with hypertension were examined by means of the Doppler examination of carotid arteries. The Holter method was used to measure 24-hour arterial blood pressure. C-reactive protein (CRP) was determined. A correlation was found between I-M and the percentage of abnormal diastolic pressure values (r=0.423, p<0.05). CRP correlated with the I-M (r=0.50, p<0.05). The measurements of the intimamedia complex should be regarded as a diagnostic factor in patients with subclinical atherosclerosis.
REFERENCES (18)
1.
Bots ML, Hoes Aw, Koudstaal PJ, Hofman A, Grobbee De: Common carotid intima-media thickness and risk of stroke and myocardial infarction: The Rotterdam Study. Circulation 1997, 96(5), 1432-1437.
 
2.
Stein JH, Fraizer MC, Aeschlimann SE, Nelson-Worel J, Mcbride PE, Douglas PS: Vascular age: integrating carotid intima-media thickness measurements with global coronary risk assessment. Clin Cardiol 2004, 27(7), 388-392.
 
3.
Mitu F, Mitu M, Turiceanu M, Tudorie C, Pandele GI: Carotid atherosclerotic alterations revealed at ultrasonografi c examination at patients with coronary heart disease Rev Med Chir Soc Med Nat Iasi 2005, 109(2), 236-241.
 
4.
Sodergard R, Backstrom T, Shanbhang V, Carstensen H: Calculation of free and bound fractions of testosterone and estadiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem 1982, 16, 801-810.
 
5.
Rinaldi S, Geay A, H. Dechaud C, Biessy C, Zeleniuch-Jacquotte A, Akhmedkhanov A, Shore Re, Roboli E, Toniolo P, Kaaks R: Validity of free testosterone and free estradiol determinations in serum samples from postmenopausal women by theoretical calculations. Cancer Epidemiol Biomarkers Prev 2002, 11, 1065-1071.
 
6.
Rexrode KM, Manson JE, Lee IM, Ridker PM, Sluss PM, Cook NR, Buring JE: Sex hormone levels and risk of cardiovascular events in postmenopausal women. Circulation 2003, 108(14), 1688-1693.
 
7.
Wang TI, Nam BH, Wilson PW, Wolf PA, Levy D, Polak JF, D’Agostino RB, O’Donnell CJ: Association of C-reactive protein with carotid atherosclerosis in men and women: The Framingham Heart Study. Arterioscler Thromb Vasc Biol 2002, 22(10), 1662-1667.
 
8.
Hashimoto H, Kitagawa K, Hougaku H, Etani H, Hori M: Relationship between C-reactive protein and progression of early carotid atherosclerosis in hypertensive subjects. Stroke 2004, 35(7), 1625-1630.
 
9.
Thakore AH, Guo CY, Larson MG, Corey D, Wang TJ, Vasan RS, D’Agostino RB SR, Lipinska I, Keaney JF JR, Benjamin EJ, O’Donnell CI.: Association of multiple infl ammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Hart Study). Am J Cardiol 2007, 99(11), 1598-1602.
 
10.
Makita S, Nakamura M, Hiramori K: The association of C-reactive protein levels with carotid intima-media complex thickness and plaque formation in the general population. Stroke 2005, 36(10), 2138- 2142.
 
11.
Kawamoto R, Tomita H, Inoue A, Ohtsuka N, Kamitani A: Impact of C-reactive protein on the likelihood of carotid atherosclerosis in Japanese adults. J Atheroscler Thromb 2006, 13(4), 175-182.
 
12.
Bernini GP, Sgro’ M, Moretti A, Argenio GF, Barlascini CO, Cristofani R, Salvetti A: Endogenous androgens and carotid intimal-medial thickness in women. J Clin Endocrinol Metab 1999, 84(6), 2008-2012.
 
13.
Golden SH, Maguire A, Ding J, Crouse JR, Cauley JA, Zacur H, Szklo M: Endogenous postmenopausal hormones and carotid atherosclerosis: a case-control study of the atherosclerosis risk in communities cohort. Am J Epidemiol 2002, 155(5), 437-445.
 
14.
Debing E, Peeters E, Duquet W, Poppe K, Velkeniers B, Van den Brande P: Endogenous sex hormone levels in postmenopausal women undergoing carotid artery endarterectomy. Eur J Endocrinol 2007, 156(6), 687-693.
 
15.
Signorelli SS, Sciacchitano S, Borzi V, Di Pino L, Costa MP, Digrandi D, Pennisi G, Marchese G, Cassibba N, Celotta G, Libertini C, Torrisi B, Caschetto S: Correlation between some metabolic markers of vascular risk and carotid artery intima-media thickness in postmenopausal women. Maturitas 2004, 49(2), 134-139.
 
16.
Tremollieres FA, Cigagna F, Alquier C, Cauneille C, Pouilles J, Ribot C: Eff ect of hormone replacement therapy on age-related increase in carotid artery intima-media thickness in postmenopausal women. Atherosclerosis 2000, 153(1), 81-88.
 
17.
Signorelli SS, Neri S, Sciacchitano S, Di Pino L, Costa MP, Pennisi G, Ierna D, Caschetto S: Duration of menopause and behavior of malondialdehyde, lipids, lipoproteins and carotid wall artery intimamedia thickness. Maturitas 2001, 39(1), 39-42.
 
18.
Signorelli SS, Sciacchitano S, Costa MP, DI Pino L, Pennnisi G, Caschetto S: Behaviour of the carotid wall in menopausal women with and without arterial hypertension. Maturitas 2000, 35(1), 39-43.
 
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