There is an abundance of diseases that cause dysfunctional bone remodeling. Some of these disorders that are commonly seen are porosis, thyrotoxicosis, Multiple Myeloma, and various cancers/neoplasms. They are all capable of causing the degeneration of bone and adversely affecting its structural integrity and stability. There are numerous etiologies that can be implicated in the degeneration of bone, spanning across many disciplines. Unless one is a specialist in all areas, discerning the correct diagnosis can be an arduous task. Usually, when there are a number of different pathologies causing a similar defect, e.g. bone degeneration, they can exhibit similar semblances. Under such circumstances an incorrect diagnosis is often made which results in practitioners administering a battery of unnecessary tests and medications. Aside from the added expense, it is also detrimental to the patient’s morbidity and mortality, as this is when the majority of unwarranted complications arise; all of which contribute to the rising costs of patient healthcare. It is the objective of the presented paper to provide the most salient information to improve the ability of general practitioners to recognize and manage these scenarios, specifically those involving the degeneration of bone. It is to be hoped that it will minimize mistakes and the financial burdens they levy. Generally, the diseases mentioned above have already been extensively researched within their individual spheres in the medical community. Although, publications specifically scrutinizing their similarities and differences within clinical constructs are sparse. In dealing with issues such as bone degeneration where it can be attributed to a multitude of causes it is often most useful to focus on those that are the most prevalent. Understanding their differences on a theoretical level can compound the benefits yielded in a clinical setting, especially with regard to diagnosis, management, and treatment.