REVIEW PAPER
Mechanisms controlling the gastrointestinal migrating motor complex
1
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Environmental and Life Sciences, Wrocław, Poland
Corresponding author
Krzysztof Romański
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Environmental and Life Sciences, C. K. Norwida 31, 50-375 Wrocław, Poland.
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Environmental and Life Sciences, C. K. Norwida 31, 50-375 Wrocław, Poland.
J Pre Clin Clin Res. 2009;3(1):11-19
KEYWORDS
ABSTRACT
The mechanisms controlling the migrating motor complex (MMC) are composed, and so far incompletely recognized. The central portion of the autonomic nervous system exerts rather modulatory effects upon the MMC although the strong inhibitory effects were also observed. The role of the enteric nervous system in the initiation and propagation of the MMC is crucial. However, these peripheral mechanisms are coordinated with central influences exerted by the extrinsic nerves. The basic role of the cholinergic system is thus combined with the adrenergic and non-adrenergic non-cholinergic influences. The hormones appear mainly to disrupt and convert the MMC cycle into the feed pattern. Several hormonal factors are also known to affect the MMC especially to induce its phase III.
REFERENCES (50)
1.
Sarna SK: Cyclic motor activity; migrating motor complex: 1985. Gastroenterology 1985, 89, 894-913.
2.
Hansen WL: Small intestinal motility. In: Johnson LR, (ed.): Physiology of the Gastrointestinal Tract. Elsevier, Amsterdam, 2006, 935-64.
3.
Torsoli A, Severi C: The neuroendocrine control of gastrointestinal motor activity. J Physiol (Paris) 1993, 87, 367-374.
4.
Vandeweerd M, Janssens J, Vantrappen G, Schippers E, Hostein J, Peeters TL: Local nerve blockade by tetrodotoxin induces ectopic phase 3 of the migrating myoelectric complex in dogs. Scand J Gastroenterol 1988, 23, 47-52.
5.
Gorard DA, Vesselinova-Jenkins CK, Libby GW, Farthing MJG: Migrating motor complex and sleep in health and irritable bowel syndrome. Dig Dis Sci 1995, 40, 2383-2389.
6.
Scott SM, Knowles CH, Wang D, Yazaki E, Picon L, Wingate DL, Lindberg G: The nocturnal jejunal migrating motor complex: defi ning normal ranges by study of 51 healthy adult volunteers and meta-analysis. Neurogastroenterol Motil 2006, 18, 927-935.
7.
Katschinski M, Dahmen G, Reinshagen M, Beglinger C, Koop H, Nustede R, Adler G: Cephalic stimulation of gastrointestinal secretory and motor responses in humans. Gastroenterology 1992, 103, 383- 391.
8.
Soff er EE, Adrian TE: Eff ect of meal composition and sham feedin on duodenojejunal motility in humans. Dig Dis Sci 1992, 37, 1009- 1014.
9.
Pouderoux P, Veyrac M, Michel H: Sham feeding disrupts phase III of the duodenal migrating motor complex in humans. Neurogastroenterol Motil 1995, 7, 139-144.
10.
Steinbach JH, Code CF: Increase in the period of the interdigestive myoelectric complex with anticipation of feeding. In: Christensen J (ed.): Gastrointestinal Motility. Raven Press, New York 1980, 247- 252.
11.
Bueno L, Fioramonti J, Fargeas MJ, Primi MP: Neurotensin: a central neuromodulator of gastrointestinal motility in the dog. Am J Physiol 1985, 248, G15-G19.
12.
Bueno L, Ferre JP: Central regulation of intestinal motility by somatostatin and cholecystokinin octapeptide. Science 1982, 216, 1427-1429.
13.
Ferre JP, Du C, Soldani G, Ruckebusch Y: Peripheral versus central components of the eff ects of dermorphin on intestinal motility in the fed rat. Reg Pept 1986, 13, 109-117.
14.
Bueno L, Fargeas MJ, Fioramonti J, Menezo Y: A tetrapeptide isolated from hamster embryo with central opiate properties on gastrointestinal motility but not on pain perception. Life Sci 1986, 39, 141-146.
15.
Bonaz B, Martin L, Beurriand E, Manier M, Hostein J, Feuerstein C: Modulation of the migrating myoelectric complex by brain noradrenergic systems in rats. Am J Physiol 1991, 260, G340-G345.
16.
Bonaz B, Martin L, Beurriand E, Manier M, Hostein J, Feuerstein C: Locus ceruleus modulates migrating myoelectric complex in rats. Am J Physiol 1992, 262, G1121-G112.
17.
Otterson MF, Sarr MG: Normal physiology of small intestinal motility. Surg Clin North Am 1993, 73, 1173-1192.
18.
Johnson CP, Sarna SK, Cowles VE, Osborn JL, Zhu YR, Bonham L, Buchmann E, Baytiych R, Telford GL, Roza AM: Motor activity and transit in the autonomically denervated jejunum. Am J Surg 1994, 167, 80-88.
19.
Siadati MR, Murr MM, Foley MK, Duenes JA, Steers JL, Sarr MG: In situ neural isolation of the entire canine upper gut: eff ects on fasting and fed motility patterns. Surgery 1997, 121, 174-181.
20.
Wang LI, Zhou L, Tian R: Role of the area postrema of medulla oblongata in the regulation of canine interdigestive migrating motor complex. Chin Med J 2002, 115, 384-388.
21.
Gleysteen JJ, Sarna SK, Myrvik AL: Canine cyclic motor activity of stomach and small bowel: the vagus is not the governor. Gastroenterology 1985, 88, 1926-1932.
22.
Hall KE, El-Sharkawy TY, Diamant NE: Vagal control of migrating motor complex in the dog. Am J Physiol 1982, 243, 276-284.
23.
Clench MH, Pineiro-Carrero VM, Mathias JR: Migrating myoelectric complex demonstrated in four avian species. Am J Physiol 1989, 256, G598-G603.
24.
Meyer JH: Motility of the stomach and gastroduodenal junction. In: Johnson LR (ed.): Physiology of the Gastrointestinal Tract. Raven Press, New York 1987, 613-629.
25.
Tanaka T, Kendrick ML, Zyromski NJ, Meile T, Sarr MG: Vagal innervation modulates motor pattern but not initiation of canine gastric migrating motor complex. Am J Physiol 2001, 281, G283-G292.
26.
Shibara C, Naito H, Ueno T, Jin X-L, Funayama Y, Fukushima K, Matsuno S, Sasaki I: Intraduodenal capsaicin inhibits gastric migrating motor complex via an extrinsic neural refl ex in conscious dogs. Neurogastroenterol Motil 2002, 14, 543-551.
27.
Gershon MD, Kirchgessner AL, Wade PR: Functional anatomy of the enteric nervous system. In: LR Johnson (ed.): Physiology of the Gastrointestinal Tract. Raven Press New York, 1994, 381-422.
28.
Jones MP, Dilley JB, Drossman D, Crowell MD: Brain-gut connections in functional GI disorders: anatomic and physiologic relationships. Neurogastroenterol Motil 2006, 18, 91-103.
29.
Valori RM, Kumar D, Wingate DL: Eff ects of diff erent types of stress and of ‘prokinetic’ drugs on the control of the fasting motor complex in humans. Gastroenterology 1986, 90, 1890-1900.
30.
Makhlouf GM: Neuromuscular function of the small intestine. In: Johnson LR (ed.): Physiology of the Gastrointestinal Tract. Raven Press, ,New York 1994, 977-990.
31.
Sarna SK: Myoelectrical and contractile activities of the gastrointestinal tract. In: Schuster MM, Crowell MD, Koch KL (eds.): Schuster Atlas of Gastrointestinal Motility in Health and Disease. BC Decker, Inc, Hamilton 2002, 1-18.
32.
Zenilman ME: Origin and control of gastrointestinal motility. Surg Clin North Am 1993, 73, 1081-1099.
33.
Tanaka M, Sarr MG: Role of the duodenum in the control of canine gastrointestinal motility. Gastroenterology 1988, 94, 622-629.
34.
Pakarinen MP, Halttunen J: The physiology of the transplanted small bowel: an overview with insight into graft function. Scand J Gastroenterol 2000, 35, 561-577.
35.
Costa A, De Ponti F, Spada M, Alessiani M, Barbera D, Ferrari P, Zanola S, Morbini P, Arbustini E, Crema A: Reduced intestinal myoelectrical activity during rejection of small bowel allografts in pigs. Transplant Proc 1996, 28, 2554-2555.
36.
Nishimoto Y, Taguchi T, Masumoto K, Ogita K, Nakamura M, Taguchi S, Uesugi T, Takada N, Suita S: Real-time monitoring for detecting rejection using strain gauge force transducers in porcine small bowel transplantation. Transplant Proc 2004, 36, 343-344.
37.
Bueno L, Ruckebusch Y: Eff ect of anticholinergic drugs on the electrical activity of the antrum and duodeno-jejunum in sheep. J Vet Pharmacol Ther 1978a, 1, 225-232.
39.
Ruckebusch Y, Malbert CH, Crichlow EC: Hexa metho nium: a probe to assess autonomic nervous system involvement in upper gastrointestinal functions in conscious sheep. Vet Res Commun 1987, 11, 293-303.
40.
El-Sharkawy TY, Markus H, Diamant NE: Neural control of the intestinal migrating myoelectric complex. A pharmacological analysis. Can J Physiol Pharmacol 1982, 60, 794-804.
41.
Ormsbee III HS, Telford GL, Mason GR: Required neural involvement in control of canine migrating motor complex. Am J Physiol 1979, 237, E451-E456.
42.
Powell AK, Bywater RAR: Murine intestinal migrating motor complexes: longitudinal components. Neurogastroenterol Motil 2003, 15, 245- 256.
43.
Sarna S, Stoddard C, Belbeck L, McWade D: Intrinsic nervous control of migrating myoelectric complex. Am J Physiol 1981, 241, G16-G23.
44.
Baccari MC, Calamai F, Staderini G: The infl uence of the vagally induced rebound contractions on the non-adrenergic, non-cholinergic (NANC) inhibitory motility of the rabbit stomach and the role of prostaglandins. J Auton Ner Syst 1992, 37, 125-135.
45.
Romański KW: The role of muscarinic and nicotinic receptors in the control of the ovine pyloric antral myoelectric response to nutrients during individual phases of the migrating myoelectric complex. Small Rumin Res 2005, 57, 121-131.
46.
Borody TJ, Clark IW, Andrews P, Hugh TB, Shortis NP: Eradication of Helicobacter pylori may not reverse severe gastric dysplasia. Am J Gastroenterol 1995, 90, 498-499.
47.
Tohara K, Uchida Y, Suzuki H, Itoh Z: Initiation of phase III contractions in the jejunum by atropine, hexamethonium and xylocaine in conscious dogs. Neurogastroenterol Motil 2000, 12, 11-21.
48.
Schiavone A. Sagrada A, Pagani F, Giachetti A: Role of muscarinic receptor subtypes in the regulation of migrating motor complex in dogs. Gastroenterology 1989, 96, 116-121.
49.
Romański KW, Goździewska-Harłajczuk K: Specifi c eff ect of pirenzepine on myoelectric and motor activity in ovine small bowel (submitted).
50.
Altaparmakov I, Wienbeck M: Adrenergic control of interdigestive migrating myoelectric complex (IDMEC). In: Wienbeck M (ed.): Motility of the Digestive Tract. Raven Press, New York 1982, 193-199.
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