The role of working memory impairment in ADHD - new therapeutic indications

Zimbul Albo 1, Alan J. Lerner 1
1 - Center for Memory and Cognition, Department of Neurology, Case Western Reserve University, Cleveland, OH USA
JPCCR
2008; 2 (1):
ICID: 981428
Article type: Review article
IC™ Value: 2.40
 
 
 Many individuals affected with Attention Deficit Hyperactivity disorder (ADHD) are faced with a constellation of symptoms and few therapeutic options. Although most of the drugs currently available for treatment are effective to some degree and target the inattention component, they lack the specificity needed to treat cognitive symptoms. Many patients complain of memory deficits as part their inability to cope with daily activities. We review here some concepts of working memory impairment in ADHD, and attempt to apply it to new therapeutic strategies that might prove valuable for treatment. Rivastigmine, a slowly reversible inhibitor of acetylcholinesterase and butyrylcholinesterase, could alleviate the cognitive symptoms of impaired attention (possibly improving working memory function) of patients with ADHD through their action on the prefrontal cholinergic system. Rivastigmine is currently used to improve cholinergic neurotransmission and cognitive function in Alzheimer’s disease (AD). Our discussion is aimed at broadening the spectrum of clinical diagnosis that could potentially benefit from it.
  FULL TEXT STATS

Recommend this article to:

First Name:
E-mail:


Related articles in IndexCopernicus™
     adhd [74 related records]
     working memory [39 related records]
     acetylcholinesterase inhibitors [9 related records]
     rivastigmine [8 related records]



 

Related articles

B Piskor-Świerad,
Wykorzystanie elementów treningu zastępowania agresji w terapii chłopca z zaburzeniami zachowania i emocji oraz ADHD
Autorka przedstawia ciekawy opis procesu terapii chłopca z zachowaniami agresywnymi. Wskazuje na znaczenie komunikacji w rodzinie i w procesie terapeutycznym obejmującym poznawczo-behawioralny trening zastępowania agresji. ...
ABSTRACT
A Mirski, M Pachalska,
AN EVALUATION OF PERSONALIZED NEUROFEEDBACK TRAINING FOR ROLANDIC EPILEPSY: A CASE STUDY
The aim of this study was to determine whether relative beta neurofeedback training (RBNT), applied to regulate brain dynamics, would be useful for a patient with benign partial epilepsy with Rolandic Spikes (BPERS), accompanied by symptoms...
ABSTRACT
M ŚWIĘCICKA,
DYLEMATY PSYCHOLOGA PRACUJĄCEGO Z RODZICAMI DZIECI Z OBJAWAMI ADHD. PROBLEM KONTROLI I WSPIERANIA AUTONOMII W WYCHOWANIU DZIECI MAJĄCYCH PROBLEMY Z SAMOKONTROLĄ ZACHOWANIA
W artykule zostały omówione trudności rodziców dzieci z objawami ADHD w sprawowaniu kontroli nad zachowaniem ich dzieci. Na podstawie danych z literatury i doświadczeń klinicznych autorki wyróżnione zostały dwie formy oddziaływań kontroluj...
ABSTRACT