The role of working memory impairment in ADHD - new therapeutic indications

Zimbul Albo 1, Alan J. Lerner 1
1 - Center for Memory and Cognition, Department of Neurology, Case Western Reserve University, Cleveland, OH USA
JPCCR
2008; 2 (1):
ICID: 981428
Article type: Review article
IC™ Value: 2.40
 
 
 Many individuals affected with Attention Deficit Hyperactivity disorder (ADHD) are faced with a constellation of symptoms and few therapeutic options. Although most of the drugs currently available for treatment are effective to some degree and target the inattention component, they lack the specificity needed to treat cognitive symptoms. Many patients complain of memory deficits as part their inability to cope with daily activities. We review here some concepts of working memory impairment in ADHD, and attempt to apply it to new therapeutic strategies that might prove valuable for treatment. Rivastigmine, a slowly reversible inhibitor of acetylcholinesterase and butyrylcholinesterase, could alleviate the cognitive symptoms of impaired attention (possibly improving working memory function) of patients with ADHD through their action on the prefrontal cholinergic system. Rivastigmine is currently used to improve cholinergic neurotransmission and cognitive function in Alzheimer’s disease (AD). Our discussion is aimed at broadening the spectrum of clinical diagnosis that could potentially benefit from it.
  FULL TEXT STATS

Recommend this article to:

First Name:
E-mail:


Related articles in IndexCopernicus™
     adhd [79 related records]
     working memory [39 related records]
     acetylcholinesterase inhibitors [10 related records]
     rivastigmine [8 related records]



 

Related articles

T Wolańczyk, A Kołakowski,
State and trait anxiety level and increase of depression among mothers of children with attention deficit hyperactivity disorder and conduct disorder. Pilot study.
Objectives: To evaluate anxiety level (as a trait and as a state) and the intensity of depressive symptoms in mothers of children with hyperkinetic disorder (HD) and with and without comorbid conduct disorder (CD); to determine the relationship betwe...
ABSTRACT
A Hunt,  Kronenberger,
PREDICTORS OF CHANGE IN SHORT-TERM MEMORY SPAN FOLLOWING WORKING MEMORY TRAINING
Background: Computer-based working memory training exercises produce improvements in performance on ability measures that are similar to the trained tasks (near-transfer), but results have been inconsistent regarding generalization of training outcom...
ABSTRACT
A Mirski, M Pachalska,
AN EVALUATION OF PERSONALIZED NEUROFEEDBACK TRAINING FOR ROLANDIC EPILEPSY: A CASE STUDY
The aim of this study was to determine whether relative beta neurofeedback training (RBNT), applied to regulate brain dynamics, would be useful for a patient with benign partial epilepsy with Rolandic Spikes (BPERS), accompanied by symptoms...
ABSTRACT