The role of working memory impairment in ADHD - new therapeutic indications

Zimbul Albo 1, Alan J. Lerner 1
1 - Center for Memory and Cognition, Department of Neurology, Case Western Reserve University, Cleveland, OH USA
JPCCR
2008; 2 (1):
ICID: 981428
Article type: Review article
IC™ Value: 2.40
 
 
 Many individuals affected with Attention Deficit Hyperactivity disorder (ADHD) are faced with a constellation of symptoms and few therapeutic options. Although most of the drugs currently available for treatment are effective to some degree and target the inattention component, they lack the specificity needed to treat cognitive symptoms. Many patients complain of memory deficits as part their inability to cope with daily activities. We review here some concepts of working memory impairment in ADHD, and attempt to apply it to new therapeutic strategies that might prove valuable for treatment. Rivastigmine, a slowly reversible inhibitor of acetylcholinesterase and butyrylcholinesterase, could alleviate the cognitive symptoms of impaired attention (possibly improving working memory function) of patients with ADHD through their action on the prefrontal cholinergic system. Rivastigmine is currently used to improve cholinergic neurotransmission and cognitive function in Alzheimer’s disease (AD). Our discussion is aimed at broadening the spectrum of clinical diagnosis that could potentially benefit from it.
  FULL TEXT STATS

Recommend this article to:

First Name:
E-mail:


Related articles in IndexCopernicus™
     adhd [82 related records]
     working memory [44 related records]
     acetylcholinesterase inhibitors [10 related records]
     rivastigmine [8 related records]



 

Related articles

A Moossavi, B Khavarghazalani,
Validity and reliability of a non-sense syllable test for evaluating phonological working memory in Persian speaking children
Background and Aim: Children with auditory processing disorders and impaired phonological working memory have difficulty in storing an accurate phonological representation of speech.Therefore, it is highly important to assess phonological working mem...
ABSTRACT
A Orylska, E Racicka,
ZASTOSOWANIA BADAŃ OKULOGRAFICZNYCH W DIAGNOZOWANIU ADHD U DZIECI W WIEKU PRZEDSZKOLNYM i WCZESNOSZKOLNYM
Prezentowana praca jest przeglądem najnowszych badań okulograficznych u osób z ADHD (zespół nadpobudliwości psychoruchowej z deficytem uwagi). W artykule wskazano na trudności diagnostyczne u dzieci z ADHD w wieku przedszkolnym i wczesnoszkoln...
ABSTRACT
I Gorzkowska, G Gorzkowski,
An interaction between a polymorphism of the serotonin transporter (5HTT) gene and the clinical picture of adolescents with combined type of ADHD (hyperkinetic disorder) and youth drinking
Introduction: The combined type of ADHD and alcohol dependence are two different disorders. Research demonstrate that 45-55% of patients diagnosed with ADHD also suffer from comorbid substance abuse, and 11-55% of patients diagnosed with substance ab...
ABSTRACT